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冠状动脉和颈动脉阻塞性疾病:单中心经验。

Coronary and carotid artery occlusive disease: single center experience.

机构信息

Institute of Cardiovascular Diseases Vojvodina, Sremska Kamenica, Serbia.

出版信息

Eur Rev Med Pharmacol Sci. 2012 Apr;16(4):483-90.

Abstract

BACKGROUND AND OBJECTIVE

Due to increased life expectancy, the risk profile of the patients undergoing cardiac surgery changed dramatically. This is especially important in case of concomitant coronary artery disease and carotid artery stenosis (CAS). Careful decision making and appropriate surgical strategy in these patients is critical for the success of the operation. Controversy about relationship between staged and concomitant carotid endarterectomy (CEA) and coronary artery bypass grafting (CABG) still exists. In the current study, we present our case lood in treating patients with concomitant carotid artery stenosis and coronary artery disease.

PATIENTS AND METHODS

CABG with additional CEA due to neurologic symptoms or high grade (>80%) CAS has been performed in 835 patients in the period of 1982-2010. Results of evaluation of perioperative mortality and morbidity in regard to the surgical approach have been discussed.

RESULTS

The average patient age was 62.6 +/- 8.7 years. Echocardiography revealed that 28% of the patients had poor left ventricle ejection fraction (<30%). Coronarography demonstrated that 21.4% of the operated patients had significant left main coronary artery stenosis (>60%). In terms of neurological status, majority of the patients (88.3%) were neurologically asymptomatic. The overall mortality regardless the sequence of procedures was 2.3% (19 patients). In the group of concomitantly treated patients 44.6% (50 patients) required triple coronary bypass while the mean number of coronary bypasses was 2.6. Postoperative neurologic complications were present in 102 patients (12.2%). Eighty-four patients (10.0%) have had TIA, while 18 patients (2.2%) have had permanent neurologic deficit while 4 patients (0.5%) died as a result of it.

CONCLUSIONS

It is imperative that every patient being considered for CABG should undergo ultrasonic evaluation of the carotid arteries regardless the neurological symptomatology. Concomitant surgery on patients with severe CAS and coronary disease carries a slightly higher operative risk and, therefore, should be avoided. Concomitant surgical treatment should only be considered in patients with unstable angina and significant CAS in whom we may expect higher morbidity and mortality.

摘要

背景与目的

由于预期寿命的延长,接受心脏手术的患者的风险状况发生了巨大变化。在同时患有冠状动脉疾病和颈动脉狭窄(CAS)的情况下,这一点尤为重要。在这些患者中,仔细的决策和适当的手术策略对于手术的成功至关重要。关于分期颈动脉内膜切除术(CEA)和冠状动脉旁路移植术(CABG)与同期颈动脉内膜切除术(CEA)与同期 CABG 之间的关系仍然存在争议。在本研究中,我们介绍了同时患有颈动脉狭窄和冠状动脉疾病的患者的治疗情况。

患者与方法

1982 年至 2010 年间,我们对 835 例因神经系统症状或高分级(>80%)CAS 而需要 CABG 并同时进行 CEA 的患者进行了 CABG。讨论了评估围手术期死亡率和发病率的手术方法。

结果

患者的平均年龄为 62.6±8.7 岁。超声心动图显示,28%的患者左心室射血分数差(<30%)。冠状动脉造影显示,21.4%的手术患者有明显的左主干冠状动脉狭窄(>60%)。在神经系统状况方面,大多数患者(88.3%)神经系统无症状。无论手术顺序如何,总的死亡率为 2.3%(19 例)。在同期治疗的患者中,44.6%(50 例)需要三冠状动脉旁路,而平均冠状动脉旁路数为 2.6。术后神经系统并发症发生在 102 例患者(12.2%)中。84 例患者(10.0%)发生短暂性脑缺血发作(TIA),18 例患者(2.2%)发生永久性神经功能缺损,4 例患者(0.5%)因此死亡。

结论

无论神经系统症状如何,每个考虑接受 CABG 的患者都应进行颈动脉超声评估。严重 CAS 和冠心病患者的同期手术风险略高,因此应避免。同期手术治疗仅应考虑在不稳定型心绞痛和明显 CAS 的患者中进行,因为我们可能会预期更高的发病率和死亡率。

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