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同期颈动脉内膜切除术与心脏手术:386例患者的早期结果

Simultaneous carotid endarterectomy and cardiac surgery: early results of 386 patients.

作者信息

Gansera Brigitte, Schmidtler Fabian, Weingartner Josef, Kiask Theodor, Gundling Felix, Hapfelmeier Alexander, Eichinger Walter

机构信息

Department of Cardiovascular Surgery, Clinic Bogenhausen, Munich, Germany.

出版信息

Thorac Cardiovasc Surg. 2012 Dec;60(8):508-16. doi: 10.1055/s-0032-1311533. Epub 2012 Jul 12.

Abstract

BACKGROUND

The occurrence of severe carotid artery disease in more than 12% of patients requiring coronary artery bypass grafting (CABG) results in a discrepancy concerning best treatment for both diseases. We reviewed the early outcome of patients with CABG and/or valve replacement (VR) and simultaneous carotid endarterectomy (CEA).

METHODS

We retrospectively evaluated 386 patients after simultaneous operation between 7/1994 and 9/2010. Total 326 patients received isolated CABG, 56 CABG and/ or VR, 4 aortic surgery. Mean age was 68.3 years (range: 45 to 87). Male patients were 229. Severity of stenosis at operated side was 70 to 80% in 167, 80 to 99% in 219 patients. Total 164 patients showed bilateral carotid stenosis, 32 had contralateral occlusion. We analyzed risk factors, morbidity, incidence of neurological events, and 30-day mortality.

RESULTS

Perioperative stroke with hemiplegia occurred in 10 patients (2.6%). Three patients experienced PRIND, seven TIA. A 30-day mortality was 5.2%. Total 8 deaths were cardiac related, 10 due to extracardial reasons, and 2 patients developed a cerebral death.

CONCLUSIONS

Simultaneous CEA and cardiac surgery can be performed with a low risk for neurological complications and acceptable mortality. Occlusion of contralateral carotid artery could be identified as an evident predictor for increased neurological complications.

摘要

背景

在需要冠状动脉搭桥术(CABG)的患者中,超过12%发生严重颈动脉疾病,这导致了对于这两种疾病的最佳治疗存在差异。我们回顾了接受冠状动脉搭桥术和/或瓣膜置换术(VR)并同时行颈动脉内膜切除术(CEA)患者的早期结局。

方法

我们回顾性评估了1994年7月至2010年9月间同时进行手术的386例患者。其中326例患者接受单纯冠状动脉搭桥术,56例接受冠状动脉搭桥术和/或瓣膜置换术,4例接受主动脉手术。平均年龄为68.3岁(范围:45至87岁)。男性患者229例。手术侧狭窄严重程度为70%至80%的有167例,80%至99%的有219例。共有164例患者表现为双侧颈动脉狭窄,32例对侧闭塞。我们分析了危险因素、发病率、神经事件发生率和30天死亡率。

结果

围手术期发生偏瘫性卒中的有10例(2.6%)。3例发生术后认知功能障碍(PRIND),7例发生短暂性脑缺血发作(TIA)。30天死亡率为5.2%。死亡的8例与心脏相关,10例为心外原因,2例发生脑死亡。

结论

同时进行颈动脉内膜切除术和心脏手术,神经并发症风险低,死亡率可接受。对侧颈动脉闭塞可被确定为神经并发症增加的明显预测因素。

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