Wong Joseph C H, Travers Catherine, O'Neill Sheila, Khoo Soo Keat
Betty Byrne Henderson Women's Health Research Centre, Royal Brisbane and Women's Hospital, Herston, Brisbane, Queensland, Australia.
J Med Imaging Radiat Oncol. 2012 Jun;56(3):302-4. doi: 10.1111/j.1754-9485.2012.02370.x. Epub 2012 Apr 10.
Bone densitometry in Australia uses the data from the Geelong Osteoporosis Study for conversion of bone mineral density (BMD) to T-scores to diagnose osteoporosis based on the World Health Organization (WHO) classification criteria. An underlying assumption is that the bone status of women in Geelong city is representative of the rest of Australia. The aim of this study is to compare the prevalence of normal BMD, osteopenia and osteoporosis of sample Brisbane women to Geelong, and to assess the validity of the Geelong reference database for Australia-wide application.
The subjects were recruited as part of a longitudinal assessment of age-related changes in a random sample of women from Brisbane. The sample consisted of 503 women, aged between 40 and 79 years. Each subject had BMD measured at the lumbar spine and femoral neck.
Using the WHO osteoporosis classification criteria based on T-scores, and the BMD cut-offs from the Geelong Study, the prevalence of normal BMD, osteopenia and osteoporosis was determined for the following age groupings, 40-44, 45-49, 50-54, 55-59, 60-64, 65-69 and 70-79, to match the Geelong Study for comparison. There were no systematic differences in the prevalence of normal BMD, osteopenia and osteoporosis in the Brisbane subjects compared to the Geelong Study.
This finding supports the use of the Geelong data as the reference for the generation of T-scores for bone densitometry assessment for osteoporosis using dual-energy X-ray absorptiometry in Australia.
澳大利亚的骨密度测量采用来自吉朗骨质疏松症研究的数据，将骨矿物质密度（BMD）转换为T值，以便根据世界卫生组织（WHO）的分类标准诊断骨质疏松症。一个潜在的假设是，吉朗市女性的骨骼状况代表了澳大利亚其他地区。本研究的目的是比较布里斯班女性样本与吉朗女性正常BMD、骨量减少和骨质疏松症的患病率，并评估吉朗参考数据库在澳大利亚范围内应用的有效性。
这些受试者是从布里斯班的女性随机样本中招募的，作为与年龄相关变化的纵向评估的一部分。样本包括503名年龄在40至79岁之间的女性。每位受试者均测量了腰椎和股骨颈的BMD。
根据基于T值的WHO骨质疏松症分类标准以及吉朗研究中的BMD临界值，确定了以下年龄组（40 - 44岁、45 - 49岁、50 - 54岁、55 - 59岁、60 - 64岁、65 - 69岁和70 - 79岁）正常BMD、骨量减少和骨质疏松症的患病率，以与吉朗研究进行匹配比较。与吉朗研究相比，布里斯班受试者中正常BMD、骨量减少和骨质疏松症的患病率没有系统性差异。
这一发现支持将吉朗的数据用作澳大利亚使用双能X线吸收法进行骨质疏松症骨密度测量评估时生成T值的参考。
