A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Suite 2301, Charlestown, Massachusetts 02129, USA.
J Am Chem Soc. 2012 Jul 4;134(26):10799-802. doi: 10.1021/ja3045635. Epub 2012 Jun 20.
Here we report a generalizable solid/solution-phase strategy for the synthesis of discrete bimodal fibrin-targeted imaging probes. A fibrin-specific peptide was conjugated with two distinct imaging reporters at the C- and N-termini. In vitro studies demonstrated retention of fibrin affinity and specificity. Imaging studies showed that these probes could detect fibrin over a wide range of probe concentrations by optical, magnetic resonance, and positron emission tomography imaging.
在这里，我们报告了一种可推广的固态/溶液相策略，用于合成离散的双模态纤维蛋白靶向成像探针。将纤维蛋白特异性肽与两个不同的成像报告器在 C 端和 N 端连接。体外研究表明保留了纤维蛋白亲和力和特异性。成像研究表明，这些探针可以通过光学、磁共振和正电子发射断层扫描成像在广泛的探针浓度范围内检测纤维蛋白。
