Multidisciplinary Cardiovascular Research Centre, The University of Leeds, Leeds, UK.
Int J Clin Pract. 2012 Jul;66(7):640-7. doi: 10.1111/j.1742-1241.2012.02924.x.
Diabetes mellitus is a risk factor for the development of coronary artery disease and chronic heart failure. When carefully screened for, diabetes or prediabetic disorders, are present in the majority of patients with clinically manifest ischaemic heart disease, and confer a major adverse impact upon morbidity and mortality. Important therapeutic modifications are required in the management of coronary artery disease and chronic heart failure associated with diabetes, and vice versa. However, despite optimal management, aided by recent landmark trials solely recruiting patients with diabetes, outcomes for patients with diabetes and heart disease remain poor. This review outlines the epidemiology, pathogenesis and management of diabetic heart disease, along with highlighting the many gaps in the evidence-base and suggesting future research priorities.
糖尿病是冠状动脉疾病和慢性心力衰竭发展的一个危险因素。在对临床上表现为缺血性心脏病的大多数患者进行仔细筛查时，会发现糖尿病或糖尿病前期障碍，这会对发病率和死亡率产生重大不利影响。需要对与糖尿病相关的冠状动脉疾病和慢性心力衰竭的管理进行重要的治疗修改，反之亦然。然而，尽管最近的标志性试验仅招募了糖尿病患者，在最佳管理的帮助下，糖尿病和心脏病患者的治疗结果仍然很差。本综述概述了糖尿病性心脏病的流行病学、发病机制和管理，同时强调了证据基础中的许多空白，并提出了未来的研究重点。
