Bamosa Abdullah, Kaatabi Huda, Badar Ahmed, Al-Khadra Akram, Al Elq Abdulmohsen, Abou-Hozaifa Bodour, Lebda Fatma, Al-Almaie Sameeh
Department of Physiology, College of Medicine, University of Dammam, Dammam, Kingdom of Saudi Arabia.
Department of Medicine, College of Medicine, University of Dammam, Dammam, Kingdom of Saudi Arabia.
J Family Community Med. 2015 May-Aug;22(2):88-95. doi: 10.4103/2230-8229.155380.
To study the effect of Nigella sativa supplementation on cardiac functions in Type 2 diabetic patients treated with oral hypoglycemic agents.
Diabetes mellitus is associated with a high risk of cardiovascular morbidity and mortality. A number of reported beneficial effects of N. sativa on cardiovascular function were the inspiration for this study.
Sixty patients with uncontrolled diabetes (hemoglobin A1c [HbA1c] >7%) and with no known cardiovascular complications were recruited from the outpatient diabetes clinic. They were assigned, by convenience, to two groups; the control group received activated charcoal as placebo while the test group received 2 g/day of powdered N. sativa for 1-year. All patients continued with their standard oral hypoglycemic agents. Echocardiography was used to evaluate the diastolic function, systolic function, and left ventricular mass (LVM) before the intervention and after 6 and 12 months of the treatment.
HbA1c decreased significantly in the N. sativa group but did not change in the control group. Echocardiographic assessment in the control group showed impairment in diastolic function after 12 months, but there were no significant changes in fractional shortening (FS) or ejection fraction (EF). Furthermore, left ventricular (LV) dimensions at diastole and systole, LVM, and LVM index were significantly increased. In N. sativa group, no significant changes were found in diastolic function or LVM. LV dimension at systole was decreased while FS and EF were significantly increased after 6 and 12 months.
N. sativa supplementation may protect the hearts of type 2 diabetic patients from diastolic dysfunction while improving LV systolic function.
研究补充黑种草籽对接受口服降糖药治疗的2型糖尿病患者心脏功能的影响。
糖尿病与心血管疾病的高发病率和死亡率相关。多项报道称黑种草籽对心血管功能有有益作用，这为本研究提供了灵感。
从门诊糖尿病诊所招募60例糖尿病控制不佳（糖化血红蛋白[HbA1c]>7%）且无已知心血管并发症的患者。根据便利原则将他们分为两组；对照组接受活性炭作为安慰剂，试验组接受2克/天的黑种草籽粉，为期1年。所有患者继续服用标准口服降糖药。在干预前以及治疗6个月和12个月后，使用超声心动图评估舒张功能、收缩功能和左心室质量（LVM）。
黑种草籽组的HbA1c显著降低，而对照组未发生变化。对照组的超声心动图评估显示，12个月后舒张功能受损，但缩短分数（FS）或射血分数（EF）无显著变化。此外，舒张期和收缩期的左心室（LV）尺寸、LVM和LVM指数均显著增加。在黑种草籽组中，舒张功能或LVM未发现显著变化。6个月和12个月后，收缩期LV尺寸减小，而FS和EF显著增加。
补充黑种草籽可能保护2型糖尿病患者的心脏免受舒张功能障碍的影响，同时改善LV收缩功能。
