Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Int J Clin Pract. 2012 Jul;66(7):663-70. doi: 10.1111/j.1742-1241.2012.02951.x.
Standardised traditional outcome measures may fail to address factors that are important to patients and address irrelevant factors. Aim of this study was to assess patient-reported goals and goal achievement (GA) in the antimuscarinic treatment for overactive bladder (OAB) patients.
Men and women aged ≥ 18 years with OAB symptoms were eligible for the study. Treatment began with a dose of 10 mg oxybutynin, to be increased if necessary to 30 mg. Before treatment, each patient's primary treatment goal was identified. After 12-week treatment, patients reported GA using a Likert scale from 0 (no achievement) to 5 (complete achievement). Successful achievement was defined as a score of 4 or 5. Traditional outcome measures including voiding diaries, the OAB questionnaire short form, patient perception of bladder condition, and treatment benefit and satisfaction were assessed. Baseline characteristics affecting GA and the correlation between GA and traditional outcome measures were evaluated.
A total of 303 goals were identified from 303 patients (51 men, 252 women). Of those, 72.3% addressed symptom relief and frequency as the most common target symptom. Other goals addressed were improving quality of life (13.5%) and eliminating coping behaviours (14.2%). After treatment, 42% had a successful GA with a median score of 3 (interquartile range; 2-4). Age had a negative effect on GA. Goal achievement was the outcome measure most correlated with treatment benefit and satisfaction.
Goal achievement can be a valuable outcome measure in OAB patients, addressing individual treatment goals and reflecting treatment benefit and patient satisfaction.
标准化的传统结局指标可能无法解决对患者重要的因素，并涉及不相关的因素。本研究旨在评估抗胆碱能药物治疗膀胱过度活动症（OAB）患者的患者报告目标和目标达成（GA）。
年龄≥18 岁、有 OAB 症状的男性和女性有资格参加这项研究。治疗从 10mg 奥昔布宁开始，如果需要，可以增加到 30mg。在治疗前，确定每位患者的主要治疗目标。治疗 12 周后，患者使用 0（无达成）到 5（完全达成）的李克特量表报告 GA。成功达成的定义是得分为 4 或 5。评估了传统的结局指标，包括排尿日记、OAB 问卷短表、患者对膀胱状况的感知以及治疗获益和满意度。评估了影响 GA 的基线特征以及 GA 与传统结局指标之间的相关性。
从 303 名患者（51 名男性，252 名女性）中确定了 303 个目标。其中，72.3%的目标是缓解症状和减少频率，这是最常见的目标症状。其他目标是提高生活质量（13.5%）和消除应对行为（14.2%）。治疗后，42%的患者 GA 成功，中位数得分为 3（四分位距；2-4）。年龄对 GA 有负面影响。GA 是与治疗获益和满意度相关性最强的结局指标。
GA 可以成为 OAB 患者有价值的结局指标，解决个体治疗目标，并反映治疗获益和患者满意度。
