Liu Siguan, Qu Xin, Liu Feng, Wang Chunting
Department of Critical Care Medicine, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China ; Department of Emergency, Zaozhuang Municipal Hospital, Zaozhuang, Shandong 277101, China.
Department of Critical Care Medicine, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China ; Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.
Mediators Inflamm. 2014;2014:421429. doi: 10.1155/2014/421429. Epub 2014 Nov 3.
The long pentraxin 3 (PTX3) is a key component of the humoral arm of the innate immune system. PTX3 is produced locally in response to proinflammatory stimuli. We reviewed the usefulness of systemic levels of PTX3 in critically ill patients with systemic inflammatory response syndrome (SIRS), sepsis, and bacteremia, focusing on its diagnostic and prognostic value.
A PubMed search on PTX3 was conducted. The list of papers was narrowed to original studies of critically ill patients. Eleven papers on original studies of critically ill patients that report on PTX3 in SIRS, sepsis, or bacteremia were identified.
Systematic levels of PTX3 have little diagnostic value in critically ill patients with SIRS, sepsis, or bacteremia. Systemic levels of PTX3, however, have superior prognostic power over other commonly used biological markers in these patients. Systemic levels of PTX3 correlate positively with markers of organ dysfunction and severity-of-disease classification system scores. Finally, systemic levels of PTX3 remain elevated in the acute phase and decreased on recovery. Notably, the age of the patients and underlying disease affect systemic levels of PTX3.
The diagnostic value of PTX3 is low in patients with sepsis. Systemic levels of PTX3 have prognostic value and may add to prognostication of patients with SIRS or sepsis, complementing severity-of-disease classification systems and other biological markers.
长五聚体蛋白3（PTX3）是先天性免疫系统体液免疫的关键组成部分。PTX3在局部由促炎刺激产生。我们回顾了全身性炎症反应综合征（SIRS）、脓毒症和菌血症重症患者中PTX3全身水平的效用，重点关注其诊断和预后价值。
在PubMed上搜索PTX3。将论文列表缩小至重症患者的原始研究。确定了11篇关于重症患者原始研究的论文，这些论文报告了SIRS、脓毒症或菌血症患者的PTX3情况。
PTX3的全身水平在SIRS、脓毒症或菌血症重症患者中诊断价值不大。然而，在这些患者中，PTX3的全身水平比其他常用生物标志物具有更强的预后预测能力。PTX3的全身水平与器官功能障碍标志物及疾病严重程度分类系统评分呈正相关。最后，PTX3的全身水平在急性期持续升高，恢复时下降。值得注意的是，患者年龄和基础疾病会影响PTX3的全身水平。
PTX3在脓毒症患者中的诊断价值较低。PTX3的全身水平具有预后价值，可能有助于SIRS或脓毒症患者的预后评估，补充疾病严重程度分类系统和其他生物标志物。
