Department of Gastroenterology, University of Tokyo, Tokyo, Japan.
Pancreas. 2012 Nov;41(8):1241-6. doi: 10.1097/MPA.0b013e31824f5970.
We examined whether the presence of pancreatic cysts could be a risk for pancreatic cancer by comparing the incidence and characteristics of cysts found by magnetic resonance (MR) imaging in patients with and without pancreatic cancer.
Half-Fourier rapid acquisition with relaxation enhancement images and MR cholangiopancreatography were performed in 116 patients with pancreatic cancer (PC group) and 1226 with nonpancreatic disease (NP group). Incidence and characteristics of cysts were analyzed.
Pancreatic cysts were detected in 65 patients (56%) of the PC group and in 123 patients (10%) of the NP group. According to the multivariate analysis, cyst presence was a significant risk factor for pancreatic cancer (odds ratio [OR], 10.27; P < 0.01), especially cysts larger than 10 mm (OR, 4.718; P < 0.01). When the definition of cyst presence in the PC group was restricted to the 33 cases with cysts considered to have existed before the development of cancer, the incidence was still high (OR, 2.976; P < 0.01) and size remained significant (OR, 4.428; P < 0.01).
Patients with pancreatic cysts, especially larger than 10 mm, were considered to be at an increased risk of pancreatic cancer over the entire pancreas.
通过比较胰腺癌患者和非胰腺疾病患者磁共振成像（MR）检查中胰腺囊肿的发生率和特征，研究胰腺囊肿是否为胰腺癌的危险因素。
对 116 例胰腺癌（PC 组）和 1226 例非胰腺疾病患者（NP 组）进行半傅里叶快速获取弛豫增强图像和 MR 胰胆管成像。分析囊肿的发生率和特征。
PC 组 65 例（56%）和 NP 组 123 例（10%）患者检测到胰腺囊肿。多因素分析显示，囊肿存在是胰腺癌的显著危险因素（比值比[OR]，10.27；P < 0.01），尤其是大于 10mm 的囊肿（OR，4.718；P < 0.01）。当将 PC 组中囊肿存在的定义限制为在癌症发生前已存在的 33 例囊肿时，其发生率仍然较高（OR，2.976；P < 0.01），且大小仍具有显著意义（OR，4.428；P < 0.01）。
患有胰腺囊肿的患者，尤其是大于 10mm 的囊肿，被认为整个胰腺患胰腺癌的风险增加。
