Tatke M, Malik G B
Department of Pathology GB Pant Hospital, New Delhi, India.
J Trop Med Hyg. 1990 Dec;93(6):377-82.
Histopathological changes in the lung resulting from infection with a virulent strain of the malarial parasite, Plasmodium knowlesi, in healthy and protein-deprived Rhesus monkeys were studied. Pertinent changes noted were a high degree of parasitized red cells in septal capillaries, microinfarcts, alveolar and interstitial oedema, interstitial pneumonitis, bronchopneumonia, and injury to septal capillary wall which may be secondary to the production of tumour necrosis factor. These changes were more marked in the non-protein-deprived monkeys.
研究了感染恶性疟原虫（诺氏疟原虫）强毒株后，健康和蛋白质缺乏的恒河猴肺部的组织病理学变化。观察到的相关变化包括：间隔毛细血管中高度寄生的红细胞、微梗死、肺泡和间质水肿、间质性肺炎、支气管肺炎，以及间隔毛细血管壁损伤，后者可能继发于肿瘤坏死因子的产生。这些变化在非蛋白质缺乏的猴子中更为明显。
