Tatke M, Bazaz-Malik G
Indian J Med Res. 1989 Nov;89:404-10.
Healthy and protein deprived rhesus monkeys were inoculated with a virulent strain of Plasmodium knowlesi, to determine the morphological changes in the brain and to establish whether this model could be utilised as an experimental model for cerebral malaria. The histomorphological changes produced in the brain did not correspond with the changes conforming to those of cerebral malaria. The changes observed in healthy controls were cerebral oedema, high percentage of parasitised RBCs in the cerebral capillaries, with prominent and, at places, disrupted endothelium. In the protein deprived animals, cerebral oedema was the only conspicuous feature. It appears that the P. knowlesi-rhesus monkey combination is not suitable as an experimental model for cerebral malaria.
对健康和蛋白质缺乏的恒河猴接种恶性疟原虫的强毒株，以确定大脑中的形态变化，并确定该模型是否可作为脑型疟疾的实验模型。大脑中产生的组织形态学变化与符合脑型疟疾的变化不相符。在健康对照中观察到的变化是脑水肿、脑毛细血管中被寄生红细胞的高比例，内皮细胞突出且在某些部位中断。在蛋白质缺乏的动物中，脑水肿是唯一明显的特征。看来，诺氏疟原虫-恒河猴组合不适合作为脑型疟疾的实验模型。
