Gill Rai B S, Day Amy, Barstow Amy, Zaman Gul, Chenu Chantal, Dhoot Gurtej K
Department of Basic Sciences, The Royal Veterinary College, University of London, Royal College Street, London, NW1 OTU, UK.
Tumour Biol. 2012 Oct;33(5):1669-80. doi: 10.1007/s13277-012-0423-2. Epub 2012 Jun 15.
SULF1/SULF2 enzymes regulate the activities of several growth factors by selective hydrolysis of 6-O-sulphates of heparan sulphate proteoglycan co-receptors, the sulfation of which is essential for signal transduction of some ligand/receptor interactions but not others. This study demonstrates the existence of SULF1 variants with a wide spectrum of splicing patterns in mammalian tumours. The levels and relative proportions of SULF1/SULF2 splice variants markedly vary in different tumours with a potential to regulate cell growth differentially. Although mammalian Sulf1 compared with Sulf2 gene generates a much larger number of splice variants, both enzymes follow generally similar distribution and signalling association trends in hepatocellular carcinomas.
硫酸酯酶1/硫酸酯酶2（SULF1/SULF2）通过对硫酸乙酰肝素蛋白聚糖共受体的6-O-硫酸盐进行选择性水解来调节多种生长因子的活性，其硫酸化对于某些配体/受体相互作用的信号转导至关重要，而对其他相互作用则不然。本研究证明在哺乳动物肿瘤中存在具有广泛剪接模式的SULF1变体。SULF1/SULF2剪接变体的水平和相对比例在不同肿瘤中显著不同，具有差异调节细胞生长的潜力。尽管与Sulf2基因相比，哺乳动物Sulf1产生的剪接变体数量要多得多，但在肝细胞癌中，这两种酶通常遵循相似的分布和信号关联趋势。
