Saimura Michiyo, Anan Keisei, Mitsuyama Shoshu, Ono Minoru, Toyoshima Satoshi
Department of Surgery, Kitakyushu Municipal Medical Center, 2-1-1 Bashaku, Kokurakita-ku, Kitakyushu, Fukuoka, 802-0077, Japan,
Breast Cancer. 2015 Jul;22(4):428-31. doi: 10.1007/s12282-012-0375-9. Epub 2012 Jun 15.
We herein report an extremely rare case of ductal carcinoma in situ (DCIS) arising in tubular adenoma of the breast. A 33-year-old female first noticed a mass in her right breast when she was 15 years old. The tumor had not changed in size subjectively for 18 years. She finally visited the hospital one and a half years before this presentation for an examination of her breast mass. Ultrasonography (US) showed a circumscribed mass suggesting a benign tumor, and mammography (MMG) revealed the well-defined high-density mass with a focal region of microcalcification. It was suspected to be adenosis based on a core-needle biopsy (CNB). During the regular follow-up, the microcalcification in the mass increased. She was therefore referred to our hospital for further examination. US and MMG showed a well-demarcated mass with a focal microcalcified area. US-guided CNB diagnosed it as DCIS with tubular adenoma. The patient underwent tumorectomy. Histologically, the tumor was diagnosed to be DCIS in tubular adenoma with negative surgical margins.
我们在此报告一例极为罕见的发生于乳腺管状腺瘤的导管原位癌（DCIS）病例。一名33岁女性在15岁时首次发现右乳有一肿块。18年来，该肿瘤主观上大小未变。她最终在此次就诊前一年半因乳腺肿块检查而前往医院。超声检查（US）显示为边界清晰的肿块，提示为良性肿瘤，乳腺钼靶摄影（MMG）显示为边界清晰的高密度肿块，伴有局灶性微钙化区域。基于粗针活检（CNB）怀疑为腺病。在定期随访期间，肿块内的微钙化增多。因此，她被转诊至我院进一步检查。US和MMG显示为边界清晰的肿块，伴有局灶性微钙化区域。US引导下的CNB诊断为DCIS合并管状腺瘤。患者接受了肿瘤切除术。组织学检查显示，肿瘤被诊断为管状腺瘤内的DCIS，手术切缘阴性。
