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先前特发性急性心肌梗死的潜在病因已查明。

Underlying cause discovered for a prior idiopathic AMI.

作者信息

Godfrey R, O'Hanlon R, Wilson M, Buckley J, Sharma S, Whyte G

机构信息

Centre for Sports Medicine and Human Performance, Brunel University, London, UK.

出版信息

BMJ Case Rep. 2011 Mar 29;2011:bcr0220113799. doi: 10.1136/bcr.02.2011.3799.

Abstract

The authors previously reported on an active, young male with normal coronaries who sustained an acute myocardial infarction (AMI). The acute cause was a coronary thrombus; however, the cause of this thrombus and a definitive diagnosis remained elusive for 18 months until a new series of events, including symptoms of breathlessness, dizziness and collapse led to acute hospital admission. CT scan revealed numerous deep venous thromboses in the right leg and bilateral pulmonary emboli (PE). Acute pharmacological thrombolysis eliminated breathlessness and significantly reduced the risk of mortality. Clinical consensus suggests a coagulopathy, requiring indefinite treatment with Warfarin. In young individuals presenting with AMI, lifestyle, personal, family and clinical history should be considered and coronary artery disease should not be assumed until further tests have eliminated coagulopathy. In those presenting with breathlessness and a history which includes AMI, a CT scan is indicated to eliminate concerns of venous thromboembolism generally and PE specifically where untreated survival times are short.

摘要

作者之前报道过一名活跃的年轻男性,其冠状动脉正常,却发生了急性心肌梗死(AMI)。急性病因是冠状动脉血栓形成;然而,在长达18个月的时间里,该血栓的成因及明确诊断一直不明,直到一系列新情况出现,包括呼吸困难、头晕和晕厥症状,促使患者紧急入院。CT扫描显示右腿有多处深静脉血栓形成及双侧肺栓塞(PE)。急性药物溶栓治疗消除了呼吸困难,并显著降低了死亡风险。临床共识表明存在凝血病,需要长期服用华法林进行治疗。对于出现AMI的年轻个体,应考虑其生活方式、个人、家族及临床病史,在进一步检查排除凝血病之前,不应假定为冠状动脉疾病。对于出现呼吸困难且有AMI病史的患者,建议进行CT扫描,以排除一般静脉血栓栓塞的担忧,特别是在未治疗的生存时间较短的情况下排除肺栓塞的担忧。

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