Nájera-Ortiz J C, Sánchez-Pérez H J, Ochoa-Díaz-López H, Leal-Fernández G, Navarro-Giné A
Área Académica Sociedad, Cultura y Salud, El Colegio de la Frontera Sur (Ecosur), 29290 San Cristóbal de Las Casas, Chiapas, Mexico.
Tuberc Res Treat. 2012;2012:708423. doi: 10.1155/2012/708423. Epub 2012 May 30.
Objective. To analyse survival in patients with pulmonary tuberculosis (PTB) and factors associated with such survival. Design. Study of a cohort of patients aged over 14 years diagnosed with PTB from January 1, 1998 to July 31, 2005. During 2004-2006 a home visit was made to each patient and, during 2008-2009, they were visited again. During these visits a follow-up interview was administered; when the patient had died, a verbal autopsy was conducted with family members. Statistical analysis consisted of survival tests, Kaplan-Meier log-rank test and Cox regression. Results. Of 305 studied patients, 68 had died due to PTB by the time of the first evaluation, 237 were followed-up for a second evaluation, and 10 of them had died of PTB. According to the Cox regression, age (over 45 years) and treatment duration (under six months) were associated with a poorer survival. When treatment duration was excluded, the association between poorer survival with age persisted, whereas with having been treated via DOTS strategy, was barely significant. Conclusions. In the studied area it is necessary that patients receive a complete treatment scheme, and to give priority to patients aged over 45 years.
目的。分析肺结核（PTB）患者的生存率以及与此生存率相关的因素。设计。对1998年1月1日至2005年7月31日期间确诊为PTB的14岁以上患者队列进行研究。在2004 - 2006年期间对每位患者进行了家访，并在2008 - 2009年期间再次进行家访。在这些家访期间进行了随访访谈；当患者死亡时，对其家属进行了口头尸检。统计分析包括生存测试、Kaplan - Meier对数秩检验和Cox回归。结果。在305名研究患者中，到首次评估时，有68人因PTB死亡，237人接受了第二次评估随访，其中10人死于PTB。根据Cox回归分析，年龄（45岁以上）和治疗持续时间（不足六个月）与较差的生存率相关。排除治疗持续时间因素后，较差生存率与年龄之间的关联仍然存在，而与采用直接观察治疗短程化疗（DOTS）策略进行治疗的关联则不显著。结论。在研究区域，患者有必要接受完整的治疗方案，并优先考虑45岁以上的患者。
