Section of Microbiology, Department of Hematology and Oncology "L. & A. Seragnoli", University of Bologna, 40138 Bologna, Italy.
Mediators Inflamm. 2012;2012:607276. doi: 10.1155/2012/607276. Epub 2012 May 31.
The interaction between human cytomegalovirus (HCMV) and its host is a complex process that begins with viral attachment and entry into host cells, culminating in the development of a specific adaptive response that clears the acute infection but fails to eradicate HCMV. We review the viral and cellular partners that mediate early host responses to HCMV with regard to the interaction between structural components of virions (viral glycoproteins) and cellular receptors (attachment/entry receptors, toll-like receptors, and other nucleic acid sensors) or intrinsic factors (PML, hDaxx, Sp100, viperin, interferon inducible protein 16), the reactions of innate immune cells (antigen presenting cells and natural killer cells), the numerous mechanisms of viral immunoevasion, and the potential exploitation of events that are associated with early phases of virus-host interplay as a therapeutic strategy.
人类巨细胞病毒（HCMV）与其宿主之间的相互作用是一个复杂的过程，始于病毒附着和进入宿主细胞，最终发展出一种特定的适应性反应，清除急性感染，但未能根除 HCMV。我们回顾了介导宿主对 HCMV 的早期反应的病毒和细胞伙伴，涉及病毒粒子（病毒糖蛋白）和细胞受体（附着/进入受体、 Toll 样受体和其他核酸传感器）或内在因素（PML、hDaxx、Sp100、viperin、干扰素诱导蛋白 16）之间的相互作用，先天免疫细胞（抗原呈递细胞和自然杀伤细胞）的反应，病毒免疫逃逸的众多机制，以及利用与病毒-宿主相互作用的早期阶段相关的事件作为治疗策略的潜力。
