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肌萎缩侧索硬化症患者运动想象时运动障碍与事件相关去同步化的相关性。

The correlation between motor impairments and event-related desynchronization during motor imagery in ALS patients.

机构信息

Department of Rehabilitation Medicine, Tokai University School of Medicine, and Department of Rehabilitation Medicine, National Hokone Hospital, Kanagawa, 259-1193, Japan.

出版信息

BMC Neurosci. 2012 Jun 15;13:66. doi: 10.1186/1471-2202-13-66.

DOI:10.1186/1471-2202-13-66
PMID:22703383
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3437214/
Abstract

BACKGROUND

The event-related desynchronization (ERD) in EEG is known to appear during motor imagery, and is thought to reflect cortical processing for motor preparation. The aim of this study is to examine the modulation of ERD with motor impairment in ALS patients. ERD during hand motor imagery was obtained from 8 ALS patients with a variety of motor impairments. ERD was also obtained from age-matched 11 healthy control subjects with the same motor task. The magnitude and frequency of ERD were compared between groups for characterization of ALS specific changes.

RESULTS

The ERD of ALS patients were significantly smaller than those of control subjects. Bulbar function and ERD were negatively correlated in ALS patients. Motor function of the upper extremities did was uncorrelated with ERD.

CONCLUSIONS

ALS patients with worsened bulbar scales may show smaller ERD. Motor function of the upper extremities did was uncorrelated with ERD.

摘要

背景

脑电图中的事件相关去同步（ERD）已知出现在运动想象期间，被认为反映了运动准备的皮层处理。本研究旨在检查 ALS 患者运动障碍时 ERD 的调制。从 8 名运动障碍程度不同的 ALS 患者中获得手部运动想象时的 ERD。还从具有相同运动任务的 11 名年龄匹配的健康对照者中获得 ERD。为了描述 ALS 的特异性变化，比较了组间 ERD 的幅度和频率。

结果

ALS 患者的 ERD 明显小于对照组。ALS 患者的延髓功能与 ERD 呈负相关。上肢运动功能与 ERD 无关。

结论

延髓量表恶化的 ALS 患者可能表现出较小的 ERD。上肢运动功能与 ERD 无关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca3/3437214/b9ba61af8aea/1471-2202-13-66-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca3/3437214/d48c8d8d3be3/1471-2202-13-66-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca3/3437214/99a07cd1c56b/1471-2202-13-66-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca3/3437214/b9ba61af8aea/1471-2202-13-66-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca3/3437214/d48c8d8d3be3/1471-2202-13-66-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca3/3437214/99a07cd1c56b/1471-2202-13-66-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ca3/3437214/b9ba61af8aea/1471-2202-13-66-3.jpg

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