Children's Hospital Los Angeles, Department of Pediatric Surgery, Los Angeles, CA 90027, USA.
J Pediatr Surg. 2012 Jun;47(6):1217-22. doi: 10.1016/j.jpedsurg.2012.03.026.
Solid pseudopapillary tumor (SPT) of the pancreas is a rare neoplasm. The objective of this study was to review our institution's experience and provide an update on current management in the pediatric population.
Our pathology database identified all patients with SPT for a 20-year period (1991-2011). Demographics, clinical characteristics, operative details, pathology, and outcomes data were retrospectively reviewed.
Eleven patients with SPT were identified. Most were female and Hispanic. Median age at resection was 14 years (9-17 years). Most patients presented with abdominal pain. Diagnostic imaging was most commonly an ultrasound or computed tomography. All tumors were resected en bloc. Median greatest tumor diameter was 5 cm (3.5-12 cm). Median length of stay was 8 days (5-19 days). Complications included pancreatic leak, chyle leak, delayed gastric emptying, fat malabsorption, and incisional keloid. Recurrence developed after 2.5 years in 1 patient with positive surgical margins. There were no metastases or deaths. Median follow-up was 1.4 years (0.6-5.9 years).
This pediatric series of SPT from a single institution corroborates previous reports in the literature. In our experience, SPT behaves like a low-grade malignancy and has an excellent prognosis. Surgical resection is dictated by tumor location and remains the treatment of choice.
胰腺实性假乳头状瘤（SPT）是一种罕见的肿瘤。本研究的目的是回顾我们机构的经验，并提供儿科人群中目前管理的最新信息。
我们的病理数据库确定了 20 年来（1991-2011 年）所有患有 SPT 的患者。回顾性回顾了人口统计学、临床特征、手术细节、病理和结果数据。
确定了 11 例 SPT 患者。大多数是女性和西班牙裔。切除时的中位年龄为 14 岁（9-17 岁）。大多数患者表现为腹痛。诊断性影像学最常见的是超声或计算机断层扫描。所有肿瘤均整块切除。中位最大肿瘤直径为 5 厘米（3.5-12 厘米）。中位住院时间为 8 天（5-19 天）。并发症包括胰漏、乳糜漏、胃排空延迟、脂肪吸收不良和切口瘢痕疙瘩。1 例切缘阳性患者在 2.5 年后复发。无转移或死亡。中位随访时间为 1.4 年（0.6-5.9 年）。
来自单一机构的本儿科 SPT 系列与文献中的先前报告相符。根据我们的经验，SPT 的行为类似于低度恶性肿瘤，预后良好。手术切除取决于肿瘤位置，仍然是首选治疗方法。
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