Epigenetic approaches in stem cell transplantation.
作者信息
Engel Nicole
机构信息
Großhadern Medical Center, Medical Department III, Ludwig-Maximilians-University Munich, Munich, Germany.
出版信息
Clin Epigenetics. 2011 Aug;2(2):411-6. doi: 10.1007/s13148-011-0048-0. Epub 2011 Jul 16.
Abstract
摘要
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本文引用的文献
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Sequential treatment of CD34+ cells from patients with primary myelofibrosis with chromatin-modifying agents eliminate JAK2V617F-positive NOD/SCID marrow repopulating cells.采用组蛋白修饰剂对原发性骨髓纤维化患者的 CD34+ 细胞进行序贯治疗，可消除 JAK2V617F 阳性 NOD/SCID 骨髓重建细胞。
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Alloreactive natural killer cells in hematopoietic stem cell transplantation.同种异体反应性自然杀伤细胞在造血干细胞移植中的作用。
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In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia.体内给予低甲基化药物可减轻移植物抗宿主病而不牺牲移植物抗白血病。
Blood. 2010 Jul 8;116(1):129-39. doi: 10.1182/blood-2009-12-257253. Epub 2010 Apr 27.
4
Immunomodulatory effect of 5-azacytidine (5-azaC): potential role in the transplantation setting.5-氮杂胞苷（5-azaC）的免疫调节作用：在移植环境中的潜在作用。
Blood. 2010 Jan 7;115(1):107-21. doi: 10.1182/blood-2009-03-210393. Epub 2009 Nov 3.
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Graft-versus-host disease.移植物抗宿主病
Lancet. 2009 May 2;373(9674):1550-61. doi: 10.1016/S0140-6736(09)60237-3. Epub 2009 Mar 11.
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Low-dose azacitidine after allogeneic stem cell transplantation for acute leukemia.急性白血病异基因干细胞移植后使用低剂量阿扎胞苷
Cancer. 2009 May 1;115(9):1899-905. doi: 10.1002/cncr.24198.
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Graft-versus-leukemia effects of transplantation and donor lymphocytes.移植及供体淋巴细胞的移植物抗白血病效应
Blood. 2008 Dec 1;112(12):4371-83. doi: 10.1182/blood-2008-03-077974.
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Anti-CD4-mediated selection of Treg in vitro - in vitro suppression does not predict in vivo capacity to prevent graft rejection.体外抗CD4介导的调节性T细胞选择——体外抑制作用无法预测体内预防移植排斥的能力。
Eur J Immunol. 2008 Jun;38(6):1677-88. doi: 10.1002/eji.200737562.
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Deacetylase inhibition promotes the generation and function of regulatory T cells.去乙酰化酶抑制作用可促进调节性T细胞的生成及功能。
Nat Med. 2007 Nov;13(11):1299-307. doi: 10.1038/nm1652. Epub 2007 Oct 7.
10
Epigenetic control of the foxp3 locus in regulatory T cells.调节性T细胞中foxp3基因座的表观遗传调控。
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