Domingo-Gonzalez Racquel, Moore Bethany B
Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.
Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA ; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.
Adv Neuroimmune Biol. 2014;5(3):189-197. doi: 10.3233/NIB-140079.
Epigenetic regulation of gene expression is important for normal biological processes like immune cell development, immune responses, and differentiation from hematopoietic stem cells. Furthermore, it is well understood that epigenetic mechanisms can include methylation, histone modification, and more recently, microRNAs. Interestingly, aberrant epigenetic modification can also promote pathology in many diseases like cancer. The effects of methylation on gene expression and its resulting phenotype have been extensively studied. In this review, we discuss the inhibition of innate immunity that occurs in humans and animal models post-stem cell transplant. In addition, we highlight the changes methylation and microRNA profiles have on regulating pulmonary innate immune responses in the context of hematopoietic stem cell transplantation in experimental animal models.
基因表达的表观遗传调控对于免疫细胞发育、免疫反应以及造血干细胞分化等正常生物学过程至关重要。此外，众所周知，表观遗传机制可包括甲基化、组蛋白修饰，以及最近发现的微小RNA。有趣的是，异常的表观遗传修饰也会在许多疾病（如癌症）中促进病理过程。甲基化对基因表达及其产生的表型的影响已得到广泛研究。在本综述中，我们讨论了干细胞移植后人类和动物模型中发生的先天性免疫抑制。此外，我们重点介绍了在实验动物模型的造血干细胞移植背景下，甲基化和微小RNA谱在调节肺部先天性免疫反应方面的变化。
