Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom.
Immunobiology. 2013 Mar;218(3):368-72. doi: 10.1016/j.imbio.2012.05.008. Epub 2012 May 23.
In contrast to other pneumococcal serotypes, which are thought to be T-independent antigens, type 1 Streptococcus pneumoniae polysaccharide (Sp1) is a zwitterionic polysaccharide (ZPS). It has previously been shown to be processed and presented by antigen-presenting cells utilizing the MHC-II pathway, which leads to Sp1-induced T cell proliferation, a hallmark of thymus-dependent immune responses. We used peripheral blood mononuclear cells obtained from adults enrolled in a randomised clinical trial to investigate memory B cell responses following immunisation with the 23-valent pneumococcal plain polysaccharide vaccine. Administration of this serotype 1 containing vaccine resulted in the depletion of serotype 1 antigen-specific pre-existing memory B cells compared to baseline. This finding indicates that this ZPS is not processed by a classical TD mechanism within the MHC-II pathway.
与其他被认为是 T 细胞非依赖型抗原的肺炎球菌血清型不同，1 型肺炎链球菌多糖（Sp1）是一种两性离子多糖（ZPS）。先前的研究表明，它可以被抗原呈递细胞利用 MHC-II 途径进行加工和呈递，从而导致 Sp1 诱导的 T 细胞增殖，这是 T 细胞依赖型免疫反应的一个标志。我们使用来自参加随机临床试验的成年人的外周血单核细胞，研究了接种 23 价肺炎球菌多糖疫苗后的记忆 B 细胞反应。与基线相比，给予这种包含 1 型血清型的疫苗会导致 1 型抗原特异性的预先存在的记忆 B 细胞耗竭。这一发现表明，这种 ZPS 不是通过 MHC-II 途径中的经典 TD 机制进行加工的。
