UCLA Department of Internal Medicine, Los Angeles, CA, USA.
UCLA Department of Pathology & Lab Sciences, Los Angeles, CA, USA.
Clin J Gastroenterol. 2024 Feb;17(1):65-68. doi: 10.1007/s12328-023-01862-2. Epub 2023 Oct 5.
We describe a patient with rheumatoid arthritis and Hashimoto's thyroiditis who developed chronic diarrhea and subsequently diagnosed with collagenous colitis (CC) 5 years after leflunomide initiation. Cessation of leflunomide resulted in complete resolution of diarrhea within 2 months. Although rare, leflunomide-induced colitis should be considered in patients with otherwise unexplained chronic diarrhea. Diagnosis is challenging as symptom onset can occur many years after leflunomide initiation, but diarrheal symptoms typically resolve within weeks to months of stopping the instigating drug.
我们描述了一位类风湿关节炎和桥本甲状腺炎患者，在来氟米特治疗 5 年后出现慢性腹泻，随后被诊断为胶原性结肠炎（CC）。停止来氟米特治疗后，腹泻在 2 个月内完全缓解。虽然罕见，但对于不明原因的慢性腹泻患者，应考虑来氟米特引起的结肠炎。由于症状发作可能在来氟米特治疗开始后多年才出现，因此诊断具有挑战性，但腹泻症状通常在停用诱发药物后的数周到数月内缓解。
