Barregård L, Thomassen Y, Schütz A, Marklund S L
Department of Occupational Medicine, Sahlgren's University Hospital, Göteborg, Sweden.
Sci Total Environ. 1990 Dec 1;99(1-2):37-47. doi: 10.1016/0048-9697(90)90208-c.
Levels of selenium and mercury in blood and urine were analysed in 37 male workers exposed to elemental mercury vapour in a chloralkali plant and in 39 unexposed controls of the same age. Mean urinary Hg was 223 nmol l-1 (15 nmol/mmol creatinine) in the exposed group and 26 nmol l-1 (2.0 nmol/mmol creatinine) in the controls. Mean blood and plasma Hg levels were 46 and 36 nmol l-1, respectively, in the exposed group, as compared with 17 and 7 nmol l-1 in the controls. The concentrations of Se in plasma and erythrocytes did not differ between the two groups. Urinary Se levels were, however, slightly but significantly lower in the exposed group (median values 23 vs 29 nmol/mmol creatinine), and there was a negative correlation between urinary Se and plasma Hg in the exposed group. This may be due to a retention of Se in the kidneys. In a subgroup of exposed workers and controls, glutathione peroxidase, superoxide dismutase and catalase were also analysed. No differences were found between the groups with respect to these antioxidative enzymes. The effect on Se status of moderate Hg exposure seems to be of minor clinical importance.
对氯碱厂37名接触元素汞蒸气的男性工人以及39名年龄相同的未接触对照者的血液和尿液中的硒和汞水平进行了分析。接触组的尿汞平均为223 nmol/l（15 nmol/mmol肌酐），对照组为26 nmol/l（2.0 nmol/mmol肌酐）。接触组的血液和血浆汞平均水平分别为46和36 nmol/l，而对照组分别为17和7 nmol/l。两组之间血浆和红细胞中的硒浓度没有差异。然而，接触组的尿硒水平略低但有显著差异（中位数分别为23和29 nmol/mmol肌酐），并且接触组的尿硒与血浆汞之间存在负相关。这可能是由于硒在肾脏中的潴留。在接触工人和对照者的一个亚组中，还分析了谷胱甘肽过氧化物酶、超氧化物歧化酶和过氧化氢酶。两组在这些抗氧化酶方面没有发现差异。中等程度汞接触对硒状态的影响似乎在临床上不太重要。
