多任务处理：在线粒体中具有新功能的核转录因子。
Multi-tasking: nuclear transcription factors with novel roles in the mitochondria.
机构信息
Department of Biochemistry and Molecular Biology, and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.
出版信息
Trends Cell Biol. 2012 Aug;22(8):429-37. doi: 10.1016/j.tcb.2012.05.001. Epub 2012 Jun 14.
Abstract
Coordinated responses between the nucleus and mitochondria are essential for the maintenance of homeostasis. For over 15 years, pools of nuclear transcription factors (TFs), such as p53 and nuclear hormone receptors, have been observed in the mitochondria. The contribution of the mitochondrial pool of these TFs to their well-defined biological actions is in some cases clear and in others not well understood. Recently, a small mitochondrial pool of the TF signal transducer and activator of transcription factor 3 (STAT3) was shown to modulate the activity of the electron transport chain (ETC). The mitochondrial function of STAT3 encompasses both its biological actions in the heart as well as its oncogenic effects. This review highlights advances in our understanding of how mitochondrial pools of nuclear TFs may influence the function of this organelle.
摘要
核与线粒体之间的协调反应对于维持内稳态至关重要。15 多年来，人们一直观察到核转录因子（TFs），如 p53 和核激素受体，在线粒体中存在池状结构。这些 TFs 的线粒体池对于其明确的生物学作用的贡献，在某些情况下是明确的，而在其他情况下则不太清楚。最近，研究表明，转录因子信号转导和转录激活因子 3（STAT3）的一小部分线粒体池可以调节电子传递链（ETC）的活性。STAT3 的线粒体功能既包括其在心脏中的生物学作用，也包括其致癌作用。这篇综述强调了我们对核 TFs 的线粒体池如何影响细胞器功能的理解的进展。
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