McClure Shawn A, Movahed Reza, Salama Andrew, Ord Robert A
Department of Oral and Maxillofacial Surgery, Nova Southeastern University, Fort Lauderdale-Davie, FL 33314-7796, USA.
J Oral Maxillofac Surg. 2013 Jan;71(1):178-88. doi: 10.1016/j.joms.2012.04.009. Epub 2012 Jun 16.
Metastasis to the maxillofacial region is a rare occurrence. In our retrospective study of patients with metastasis to the maxillofacial region, the subjects were evaluated to define the clinical behavior patterns in response to the treatment given.
A retrospective record review during a 15-year period (1990 to 2005) was conducted. The patients were selected for inclusion in the present study if they had histologically confirmed maxillofacial metastases.
In our retrospective study, during the 15-year period, 1,221 new patients with maxillofacial/oral cancer were seen and evaluated. Of these 1,221 patients, 26 (16 men and 10 women) were identified as having a histologically confirmed metastasis to the maxillofacial region, for an incidence of 2.1%.
Patients with metastasis to the maxillofacial region are often deemed to not be surgical candidates because of the extensive nature of the metastatic disease. We believe that surgical intervention plays a beneficial role in improving quality of life in a properly selected group of patients with metastasis to the maxillofacial region. In our case series, surgery was performed in about 50% of the patients, and palliation and radiotherapy were the most commonly used modalities.
转移至颌面区域的情况较为罕见。在我们对转移至颌面区域患者的回顾性研究中,对受试者进行评估以确定针对所给予治疗的临床行为模式。
进行了为期15年(1990年至2005年)的回顾性病历审查。如果患者经组织学证实有颌面转移,则入选本研究。
在我们的回顾性研究中,在这15年期间,共诊治并评估了1221例新的颌面/口腔癌患者。在这1221例患者中,有26例(16例男性和10例女性)经组织学证实有转移至颌面区域,发生率为2.1%。
由于转移性疾病的广泛性,转移至颌面区域的患者通常被认为不适合手术。我们认为手术干预在适当选择的转移至颌面区域的患者群体中对改善生活质量起着有益作用。在我们的病例系列中,约50%的患者接受了手术,姑息治疗和放疗是最常用的治疗方式。