Letowska M, Bykowska K, Sablinski J, Lopaciuk S, Kopeć M
Department of Blood Storage and Preparation, Institute of Hematology, Warsaw, Poland.
Thromb Haemost. 1990 Oct 22;64(2):294-6.
Plasma fibronectin (pFN), von Willebrand factor antigen (vWf:Ag), factor VIII procoagulant activity, fibrinogen, euglobulin lysis time (ELT) and hematocrit were determined in healthy blood donors before and after venostasis as well as after intravenous infusion of 1-deamino-8-D-arginine vasopressin (DDAVP). Both venostasis and DDAVP provoked an increase in vWf:Ag and shortening in the ELT. In contrast, venostasis only but not DDAVP induced an increase in pFN levels which was statistically significant with and without correction for a concomitant hematocrit increment. The results indicate that there is a distinct difference in the patterns of venostasis and DDAVP mediated release of proteins from the vessel wall.
在健康献血者静息前后以及静脉注射1-去氨基-8-D-精氨酸加压素（DDAVP）后，测定血浆纤连蛋白（pFN）、血管性血友病因子抗原（vWf:Ag）、凝血因子VIII促凝活性、纤维蛋白原、优球蛋白溶解时间（ELT）和血细胞比容。静息和DDAVP均引起vWf:Ag增加和ELT缩短。相比之下，仅静息而非DDAVP可诱导pFN水平升高，无论是否校正伴随的血细胞比容增加，该升高均具有统计学意义。结果表明，静息和DDAVP介导的血管壁蛋白释放模式存在明显差异。
