Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.
Curr Opin Biotechnol. 2012 Oct;23(5):820-5. doi: 10.1016/j.copbio.2012.05.007. Epub 2012 Jun 15.
There has been a tremendous growth in the use of biomaterials serving as cellular scaffolds for tissue engineering applications. Recently, advanced material strategies have been developed to incorporate structural, mechanical, and biochemical signals that can interact with the cell and the in vivo environment in a biologically specific manner. In this article, strategies such as the use of composite materials and material processing methods to better mimic the extracellular matrix, integration of mechanical and topographical properties of materials in scaffold design, and incorporation of biochemical cues such as cytokines in tethered, soluble, or time-released forms are presented. Finally, replication of the dynamic forces and biochemical gradients of the in vivo cellular environment through the use of microfluidics is highlighted.
生物材料在组织工程应用中作为细胞支架的使用有了巨大的增长。最近，已经开发出了先进的材料策略，将结构、机械和生化信号结合在一起，以生物特异性的方式与细胞和体内环境相互作用。在本文中，介绍了一些策略，如使用复合材料和材料加工方法来更好地模拟细胞外基质，在支架设计中整合材料的机械和形貌特性，以及以固定、可溶或定时释放的形式加入细胞因子等生化信号。最后，通过使用微流控技术复制体内细胞环境的动态力和生化梯度。
