用于指导性生物材料涂层的基于导电聚合物的多层膜。
Conducting polymer-based multilayer films for instructive biomaterial coatings.
作者信息
Hardy John G, Li Hetian, Chow Jacqueline K, Geissler Sydney A, McElroy Austin B, Nguy Lindsey, Hernandez Derek S, Schmidt Christine E
机构信息
J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA; J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA.
Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA; Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA.
出版信息
Future Sci OA. 2015 Nov 2;1(4):FSO79. doi: 10.4155/fso.15.79. eCollection 2015 Nov.
AIM
To demonstrate the design, fabrication and testing of conformable conducting biomaterials that encourage cell alignment.
MATERIALS & METHODS: Thin conducting composite biomaterials based on multilayer films of poly(3.4-ethylenedioxythiophene) derivatives, chitosan and gelatin were prepared in a layer-by-layer fashion. Fibroblasts were observed with fluorescence microscopy and their alignment (relative to the dipping direction and direction of electrical current passed through the films) was determined using ImageJ.
RESULTS
Fibroblasts adhered to and proliferated on the films. Fibroblasts aligned with the dipping direction used during film preparation and this was enhanced by a DC current.
CONCLUSION
We report the preparation of conducting polymer-based films that enhance the alignment of fibroblasts on their surface which is an important feature of a variety of tissues.
目的
展示可促进细胞排列的适形导电生物材料的设计、制造和测试。
材料与方法
基于聚（3,4-亚乙基二氧噻吩）衍生物、壳聚糖和明胶的多层膜制备了薄导电复合生物材料，采用逐层方式进行。用荧光显微镜观察成纤维细胞，并使用ImageJ确定其排列方向（相对于膜制备过程中的浸渍方向和通过膜的电流方向）。
结果
成纤维细胞在膜上黏附并增殖。成纤维细胞与膜制备过程中使用的浸渍方向对齐，并且直流电流可增强这种对齐效果。
结论
我们报道了基于导电聚合物的膜的制备，该膜可增强成纤维细胞在其表面的排列，这是多种组织的一个重要特征。
Zotero 插件