Radiology and Imaging Sciences Department and National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892, USA.
Circ Cardiovasc Imaging. 2012 Jul;5(4):500-8. doi: 10.1161/CIRCIMAGING.112.973560. Epub 2012 Jun 15.
Increased left ventricular myocardial thickness (LVMT) is a feature of several cardiac diseases. The purpose of this study was to establish standard reference values of normal LVMT with cardiac magnetic resonance and to assess variation with image acquisition plane, demographics, and left ventricular function.
End-diastolic LVMT was measured on cardiac magnetic resonance steady-state free precession cine long and short axis images in 300 consecutive participants free of cardiac disease (169 women; 65.6 ± 8.5 years) of the Multi-Ethnic Study of Atherosclerosis cohort. Mean LVMT on short axis images at the mid-cavity level was 5.3 ± 0.9 mm and 6.3 ± 1.1 mm for women and men, respectively. The average of the maximum LVMT at the mid-cavity for women/men was 7/9 mm (long axis) and 7/8 mm (short axis). Mean LVMT was positively associated with weight (0.02 mm/kg; P=0.01) and body surface area (1.1 mm/m(2); P<0.001). No relationship was found between mean LVMT and age or height. Greater mean LVMT was associated with lower left ventricular end-diastolic volume (0.01 mm/mL; P<0.01), a lower left ventricular end-systolic volume (-0.01 mm/mL; P=0.01), and lower left ventricular stroke volume (-0.01 mm/mL; P<0.05). LVMT measured on long axis images at the basal and mid-cavity level were slightly greater (by 6% and 10%, respectively) than measurements obtained on short axis images; apical LVMT values on long axis images were 20% less than those on short axis images.
Normal values for wall thickness are provided for middle-aged and older subjects. Normal LVMT is lower for women than men. Observed values vary depending on the imaging plane for measurement.
左心室心肌厚度（LVMT）增加是几种心脏病的特征。本研究的目的是建立心脏磁共振正常 LVMT 的标准参考值，并评估其随图像采集平面、人口统计学和左心室功能的变化。
在无心脏病的多民族动脉粥样硬化研究队列的 300 名连续参与者（女性 169 名；65.6±8.5 岁）中，使用心脏磁共振稳态自由进动电影长轴和短轴图像测量舒张末期 LVMT。中腔水平短轴图像上的平均 LVMT 分别为女性和男性的 5.3±0.9mm 和 6.3±1.1mm。女性/男性中腔最大 LVMT 的平均值为 7/9mm（长轴）和 7/8mm（短轴）。平均 LVMT 与体重呈正相关（0.02mm/kg；P=0.01），与体表面积呈正相关（1.1mm/m2；P<0.001）。平均 LVMT 与年龄或身高之间无相关性。较高的平均 LVMT 与较低的左心室舒张末期容积（0.01mm/mL；P<0.01）、较低的左心室收缩末期容积（-0.01mm/mL；P=0.01）和较低的左心室每搏量（-0.01mm/mL；P<0.05）相关。基底和中腔水平长轴图像上测量的 LVMT 略大于短轴图像（分别为 6%和 10%）；长轴图像上的心尖 LVMT 值比短轴图像上的低 20%。
提供了中年及以上人群的壁厚度正常值。女性的正常 LVMT 低于男性。观察值随测量的成像平面而变化。
