氟化物浓度和牛奶温度对龋齿再矿化的影响。

Effects of fluoride concentration and temperature of milk on caries lesion rehardening.

机构信息

Department of Preventive and Community Dentistry, Oral Health Research Institute, Indiana University School of Dentistry, Indianapolis, IN 46202, USA.

出版信息

J Dent. 2012 Oct;40(10):810-3. doi: 10.1016/j.jdent.2012.06.001. Epub 2012 Jun 15.

DOI:10.1016/j.jdent.2012.06.001

PMID:22706204

Abstract

OBJECTIVES

The aim of the present in vitro study was to investigate the effects of fluoride concentration and temperature of milk on caries lesion rehardening under pH cycling conditions.

METHODS

Incipient caries-like lesions were formed in human enamel specimens, characterized using Vickers surface microhardness (VHN) and assigned to seven treatment groups (n=18 per group): fluoride was tested at five levels (0, 2.5, 5, 10, 20mg/l, all 22°C) and milk temperature at three levels (4, 22, 60°C), but only for 10mg/l F. Lesions were pH cycled for 15d (4 ×/daily 10 min milk treatments, 1 ×/daily 4h acid challenge, remineralization in human/artificial saliva mixture). VHN of specimens were measured again and changes from lesion baseline were calculated. Subsequently, enamel fluoride uptake (EFU) was determined using the micro drill technique.

RESULTS

Lesions responded to fluoride in a dose-response manner with higher fluoride concentrations resulting in more lesion rehardening (20>10 ≥ 5 ≥ 2.5>0mg/lF). Furthermore, fluoridated milk at 60°C was found to be more efficacious than at 4°C (60 ≥ 22>4°C). EFU results were similar (20>10>5>2.5 ≥ 0 mg/lF; 60>22≥4°C).

CONCLUSIONS

Both fluoride concentration and milk temperature are likely to contribute to the anti-caries potential of fluoridated milk.

摘要

目的

本体外研究旨在探讨氟化物浓度和牛奶温度对 pH 循环条件下龋损再矿化的影响。

方法

在人釉质标本中形成初期龋样病变，采用维氏表面显微硬度（VHN）进行特征描述，并将其分为 7 个治疗组（每组 18 个标本）：氟化物在 5 个水平（0、2.5、5、10、20mg/L，均为 22°C）和 3 个牛奶温度水平（4、22、60°C）下进行测试，但仅在 10mg/L F 下测试牛奶温度。病变 pH 循环 15d（4×/每日 10min 牛奶处理，1×/每日 4h 酸挑战，在人/人工唾液混合物中再矿化）。再次测量标本的 VHN，并计算病变基线的变化。随后，使用微钻技术测定牙釉质氟摄取量（EFU）。