基于前额叶皮层兴奋-抑制平衡的价值引导选择机制。
A mechanism for value-guided choice based on the excitation-inhibition balance in prefrontal cortex.
机构信息
Oxford Centre for Functional MRI of the Brain, University of Oxford, John Radcliffe Hospital, Oxford, UK.
出版信息
Nat Neurosci. 2012 Jun 17;15(7):960-1. doi: 10.1038/nn.3140.
Abstract
Although the ventromedial prefrontal cortex (vmPFC) has long been implicated in reward-guided decision making, its exact role in this process has remained an unresolved issue. Here we show that, in accordance with models of decision making, vmPFC concentrations of GABA and glutamate in human volunteers predict both behavioral performance and the dynamics of a neural value comparison signal. These data provide evidence for a neural competition mechanism in vmPFC that supports value-guided choice.
摘要
虽然腹内侧前额叶皮层（vmPFC）长期以来一直被认为与奖励导向的决策有关，但它在这一过程中的具体作用仍然是一个悬而未决的问题。在这里，我们表明，与决策模型一致，人类志愿者vmPFC 中的 GABA 和谷氨酸浓度既可以预测行为表现，也可以预测神经价值比较信号的动态。这些数据为 vmPFC 中的神经竞争机制提供了证据，支持了价值导向的选择。
相似文献
1
A mechanism for value-guided choice based on the excitation-inhibition balance in prefrontal cortex.基于前额叶皮层兴奋-抑制平衡的价值引导选择机制。
Nat Neurosci. 2012 Jun 17;15(7):960-1. doi: 10.1038/nn.3140.
2
Dissociable contributions of ventromedial prefrontal and posterior parietal cortex to value-guided choice.腹内侧前额叶皮层和顶叶后皮质对价值引导选择的可分离作用。
Neuroimage. 2014 Oct 15;100:498-506. doi: 10.1016/j.neuroimage.2014.06.005. Epub 2014 Jun 15.
3
Choosing the lesser of two evils, the better of two goods: specifying the roles of ventromedial prefrontal cortex and dorsal anterior cingulate in object choice.两害相权取其轻，两利相权取其重：明确腹内侧前额叶皮质和背侧前扣带回在客体选择中的作用
J Neurosci. 2006 Nov 1;26(44):11379-86. doi: 10.1523/JNEUROSCI.1640-06.2006.
4
Dissociating contributions of ACC and vmPFC in reward prediction, outcome, and choice.区分前扣带回皮质和腹内侧前额叶皮质在奖励预测、结果及选择中的作用。
Neuropsychologia. 2014 Jul;59:112-23. doi: 10.1016/j.neuropsychologia.2014.04.019. Epub 2014 May 9.
5
Reward value comparison via mutual inhibition in ventromedial prefrontal cortex.腹内侧前额叶皮层通过相互抑制进行奖励值比较。
Neuron. 2014 Jun 18;82(6):1357-66. doi: 10.1016/j.neuron.2014.04.032. Epub 2014 May 29.
6
Neural computations underlying action-based decision making in the human brain.人类大脑基于行动的决策的神经计算。
Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17199-204. doi: 10.1073/pnas.0901077106. Epub 2009 Sep 28.
7
How self-determined choice facilitates performance: a key role of the ventromedial prefrontal cortex.自主选择如何促进表现：腹内侧前额叶皮层的关键作用。
Cereb Cortex. 2015 May;25(5):1241-51. doi: 10.1093/cercor/bht317. Epub 2013 Dec 2.
8
Identity-Specific Reward Representations in Orbitofrontal Cortex Are Modulated by Selective Devaluation.眶额皮质中特定身份的奖励表征受选择性贬值调节。
J Neurosci. 2017 Mar 8;37(10):2627-2638. doi: 10.1523/JNEUROSCI.3473-16.2017. Epub 2017 Feb 3.
9
Dissociating Value Representation and Inhibition of Inappropriate Affective Response during Reversal Learning in the Ventromedial Prefrontal Cortex.在腹内侧前额叶皮层的反转学习过程中，对价值表现和抑制不适当情感反应进行分离。
eNeuro. 2016 Jan 4;2(6). doi: 10.1523/ENEURO.0072-15.2015. eCollection 2015 Nov-Dec.
10
Value Estimation versus Effort Mobilization: A General Dissociation between Ventromedial and Dorsomedial Prefrontal Cortex.价值估计与努力调动：腹内侧前额叶皮层和背内侧前额叶皮层之间的一般分离
J Neurosci. 2024 Apr 24;44(17):e1176232024. doi: 10.1523/JNEUROSCI.1176-23.2024.
引用本文的文献
1
Orbitofrontal cortex computes gaze-dependent comparisons between attributes rather than integrated values.眶额皮质计算的是属性之间基于注视的比较，而非综合值。
PLoS Biol. 2025 Aug 7;23(8):e3003281. doi: 10.1371/journal.pbio.3003281. eCollection 2025 Aug.
2
Non-invasive brain stimulation reorganises effective connectivity during a working memory task in individuals with Neurofibromatosis Type 1.在1型神经纤维瘤病患者的工作记忆任务期间，非侵入性脑刺激可重新组织有效连接。
Neuroimage Rep. 2025 Mar 29;5(2):100258. doi: 10.1016/j.ynirp.2025.100258. eCollection 2025 Jun.
3
Bidirectional modulation of reward-guided decision making by dopamine.多巴胺对奖励引导决策的双向调节
Psychopharmacology (Berl). 2025 May 29. doi: 10.1007/s00213-025-06816-9.
4
The Relationship Among Range Adaptation, Social Anhedonia, and Social Functioning: A Combined Magnetic Resonance Spectroscopy and Resting-State fMRI Study.范围适应、社交快感缺失与社会功能之间的关系：一项磁共振波谱与静息态功能磁共振成像联合研究
Schizophr Bull. 2025 Mar 4;51(Suppl 2):S160-S172. doi: 10.1093/schbul/sbad116.
5
A study of long-term GABA and high-energy phosphate alterations in the primary motor cortex using anodal tDCS and H/P MR spectroscopy.一项使用阳极经颅直流电刺激（tDCS）和氢质子磁共振波谱（H/P MR spectroscopy）对初级运动皮层中γ-氨基丁酸（GABA）和高能磷酸酯的长期变化进行的研究。
Front Hum Neurosci. 2024 Dec 13;18:1461417. doi: 10.3389/fnhum.2024.1461417. eCollection 2024.
6
You Eat with Your Eyes: Framing of Food Choice Options Affects Decision Conflict and Visual Attention in Food Choice Task.你用眼睛进食：食物选择选项的呈现方式会影响食物选择任务中的决策冲突和视觉注意
Nutrients. 2024 Oct 1;16(19):3343. doi: 10.3390/nu16193343.
7
Inhibitory mechanisms in the prefrontal-cortex differentially mediate Putamen activity during valence-based learning.前额叶皮质中的抑制机制在基于效价的学习过程中差异介导壳核活动。
bioRxiv. 2024 Sep 26:2024.07.29.605168. doi: 10.1101/2024.07.29.605168.
8
Neural interactions in the human frontal cortex dissociate reward and punishment learning.人类前额皮质的神经相互作用分离了奖励和惩罚学习。
Elife. 2024 Jun 28;12:RP92938. doi: 10.7554/eLife.92938.
9
Multiattribute Decision-making in Macaques Relies on Direct Attribute Comparisons.猕猴的多属性决策依赖于直接属性比较。
J Cogn Neurosci. 2024 Sep 1;36(9):1879-1897. doi: 10.1162/jocn_a_02208.
10
A cerebellar granule cell-climbing fiber computation to learn to track long time intervals.小脑颗粒细胞- climbing 纤维计算以学习跟踪长时间间隔。
Neuron. 2024 Aug 21;112(16):2749-2764.e7. doi: 10.1016/j.neuron.2024.05.019. Epub 2024 Jun 12.
本文引用的文献
1
Determinants of stated willingness to pay for public goods: A study in the headline method.对公共物品支付意愿的决定因素：标题法研究
J Risk Uncertain. 1994;9(1):5-37. doi: 10.1007/BF01073401.
2
Transformation of stimulus value signals into motor commands during simple choice.简单选择过程中刺激值信号向运动指令的转换。
Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18120-5. doi: 10.1073/pnas.1109322108. Epub 2011 Oct 17.
3
Relationship between physiological measures of excitability and levels of glutamate and GABA in the human motor cortex.人类运动皮层兴奋性的生理测量与谷氨酸和 GABA 水平之间的关系。
J Physiol. 2011 Dec 1;589(Pt 23):5845-55. doi: 10.1113/jphysiol.2011.216978. Epub 2011 Oct 17.
4
Frontal cortex and reward-guided learning and decision-making.前额皮质与奖励引导的学习和决策。
Neuron. 2011 Jun 23;70(6):1054-69. doi: 10.1016/j.neuron.2011.05.014.
5
The role of GABA in human motor learning.GABA 在人类运动学习中的作用。
Curr Biol. 2011 Mar 22;21(6):480-4. doi: 10.1016/j.cub.2011.01.069. Epub 2011 Mar 3.
6
Heterogeneous coding of temporally discounted values in the dorsal and ventral striatum during intertemporal choice.在跨期选择中，背侧纹状体和腹侧纹状体对时间贴现价值的异质性编码。
Neuron. 2011 Jan 13;69(1):170-82. doi: 10.1016/j.neuron.2010.11.041.
7
A new perspective on the role of the orbitofrontal cortex in adaptive behaviour.眶额皮质在适应性行为中作用的新视角。
Nat Rev Neurosci. 2009 Dec;10(12):885-92. doi: 10.1038/nrn2753. Epub 2009 Nov 11.
8
Human reinforcement learning subdivides structured action spaces by learning effector-specific values.人类强化学习通过学习特定效应器的值来细分结构化动作空间。
J Neurosci. 2009 Oct 28;29(43):13524-31. doi: 10.1523/JNEUROSCI.2469-09.2009.
9
Neural computations underlying action-based decision making in the human brain.人类大脑基于行动的决策的神经计算。
Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17199-204. doi: 10.1073/pnas.0901077106. Epub 2009 Sep 28.
10
How green is the grass on the other side? Frontopolar cortex and the evidence in favor of alternative courses of action.对岸的草有多绿？额极皮质与支持其他行动方案的证据。
Neuron. 2009 Jun 11;62(5):733-43. doi: 10.1016/j.neuron.2009.05.014.
Zotero 插件