Oxford Centre for Functional MRI of the Brain, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Nat Neurosci. 2012 Jun 17;15(7):960-1. doi: 10.1038/nn.3140.
Although the ventromedial prefrontal cortex (vmPFC) has long been implicated in reward-guided decision making, its exact role in this process has remained an unresolved issue. Here we show that, in accordance with models of decision making, vmPFC concentrations of GABA and glutamate in human volunteers predict both behavioral performance and the dynamics of a neural value comparison signal. These data provide evidence for a neural competition mechanism in vmPFC that supports value-guided choice.
虽然腹内侧前额叶皮层（vmPFC）长期以来一直被认为与奖励导向的决策有关，但它在这一过程中的具体作用仍然是一个悬而未决的问题。在这里，我们表明，与决策模型一致，人类志愿者vmPFC 中的 GABA 和谷氨酸浓度既可以预测行为表现，也可以预测神经价值比较信号的动态。这些数据为 vmPFC 中的神经竞争机制提供了证据，支持了价值导向的选择。
