IL23R 多态性与银屑病和银屑病关节炎的关联：一项荟萃分析。
Association of IL23R polymorphisms with psoriasis and psoriatic arthritis: a meta-analysis.
机构信息
Department of Dermatology, Affiliated Hospital of Guangdong Medical College, No. 57, Remnin Avenue, Xiashan District, Zhanjiang, Guangdong 524001, China.
出版信息
Inflamm Res. 2012 Oct;61(10):1149-54. doi: 10.1007/s00011-012-0509-8. Epub 2012 Jun 17.
BACKGROUND
The association of variants in the IL23R gene with psoriasis and psoriatic arthritis (PsA) is a robust genetic finding
OBJECTIVES
To assess whether combined evidence shows the association between IL23R polymorphisms and susceptibility to psoriasis/PsA.
METHODS
We conducted a meta-analysis to examine the association between the IL23R rs11209026 (Q381R), rs7530511 (L310P), and rs2201841 polymorphisms and psoriasis/PsA.
RESULTS
Thirteen articles met the inclusion criteria and contributed data to the meta-analysis. For rs11209026, the odds ratios (ORs) of minor alleles for psoriasis and PsA were 0.616 [95 % confidence interval (CI) 0.563-0.674] and 0.630 (95 % CI 0.524-0.757), respectively. For rs7530511, the pooled ORs were 0.820 (95 % CI 0.764-0.879) for psoriasis and 0.875 (95 % CI 0.766-1.000) for PsA; for rs2201841 the OR was 1.121 (95 % CI 1.031-1.219) for psoriasis. In genotypic analysis, the association of rs11209026 (A) and rs7530511 (T) were compatible with the dominant model (P < 0.0001, P = 0.001 respectively). The overall ORs for GG vs. AA (OR 1.339; 95 % CI 1.151-1.558), GG vs. GA (OR 1.143; 95 % CI 1.004-1.300), dominant (OR 1.226; 95 % CI 1.143-1.316), and recessive (OR 1.254; 95 % CI 1.115-1.411) models of rs2201841 were all significantly increased in psoriasis. No publication bias was present.
CONCLUSIONS
Our results demonstrate a significant association between IL23R gene polymorphisms and psoriasis/PsA.
背景
白细胞介素 23 受体（IL23R）基因变异与银屑病和银屑病关节炎（PsA）的关联是一个强有力的遗传发现。
目的
评估 IL23R 多态性与银屑病/PsA 易感性之间的综合证据是否存在关联。
方法
我们进行了一项荟萃分析，以研究 IL23R rs11209026（Q381R）、rs7530511（L310P）和 rs2201841 多态性与银屑病/PsA 之间的关联。
结果
符合纳入标准的 13 篇文章为荟萃分析提供了数据。对于 rs11209026，银屑病和 PsA 的次要等位基因的优势比（ORs）分别为 0.616（95%置信区间[CI]0.563-0.674）和 0.630（95%CI0.524-0.757）。对于 rs7530511，银屑病的合并 OR 为 0.820（95%CI0.764-0.879），PsA 的合并 OR 为 0.875（95%CI0.766-1.000）；rs2201841 的 OR 为 1.121（95%CI1.031-1.219）。在基因型分析中，rs11209026（A）和 rs7530511（T）与显性模型相匹配（P<0.0001，P=0.001）。GG 与 AA（OR1.339；95%CI1.151-1.558）、GG 与 GA（OR1.143；95%CI1.004-1.300）、显性（OR1.226；95%CI1.143-1.316）和隐性（OR1.254；95%CI1.115-1.411）模型的总体 OR 均显著增加。未发现发表偏倚。
结论
我们的结果表明白细胞介素 23 受体基因多态性与银屑病/PsA 之间存在显著关联。
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