评估白细胞介素-23 受体（IL-23R）基因多态性和银屑病患者血清 IL-23 水平。
Evaluation of interleukin-23 receptor (IL-23R) gene polymorphisms and serum IL-23 levels in patients with psoriasis.
机构信息
Department of Dermatology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey
Department of Medical Genetics, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey
出版信息
Turk J Med Sci. 2019 Oct 24;49(5):1386-1394. doi: 10.3906/sag-1904-48.
BACKGROUND/AIM: IL-23R gene polymorphisms and the association of these polymorphisms with serum IL-23 levels were investigated in patients with psoriasis in the current study.
MATERIALS AND METHODS
Sixty-seven patients with psoriasis who were admitted to our dermatology outpatient clinic and 67 healthy controls were included in the study. Polymorphisms of the IL-23R gene were determined by KASP-PCR method, and serum IL-23 levels were determined by ELISA method.
RESULTS
The distribution of IL-23R gene polymorphisms rs2201841, rs11209026, rs7530511, rs1343152, and rs11465804 was not significantly different in the patient and control groups. The AA genotype of the rs2201841 locus in males and the GA genotype in females, as well as the AA genotype of the rs1343152 locus in males and the CA genotype in females, were statistically significant in patients with psoriasis. The mean serum IL-23 level was significantly lower in the patient group (42.62 ± 5.96) compared to the control groups (75.76 ± 13.24).
CONCLUSION
IL-23R gene polymorphisms including rs2201841, rs11209026, rs7530511, rs11465804, and rs1343152 were not found to be significantly related to psoriasis. Different genetic polymorphisms may play a role in the development of psoriasis in female and male populations. Ethnic differences between different populations may have led to differences in the distribution of polymorphisms in the current study with compared to other published studies. Additionally, many different genes, polymorphisms, and environmental factors that have an effect on the development of psoriasis may affect the disease process.
背景/目的：本研究旨在探讨白细胞介素 23 受体（IL-23R）基因多态性及其与血清 IL-23 水平的关系。
材料与方法
将 67 例银屑病患者和 67 例健康对照纳入本研究。采用 KASP-PCR 法检测 IL-23R 基因多态性，采用 ELISA 法检测血清 IL-23 水平。
结果
患者组和对照组 IL-23R 基因多态性 rs2201841、rs11209026、rs7530511、rs1343152 和 rs11465804 的分布无显著差异。男性 rs2201841 位点的 AA 基因型和女性的 GA 基因型，以及男性 rs1343152 位点的 AA 基因型和女性的 CA 基因型在银屑病患者中具有统计学意义。银屑病患者的平均血清 IL-23 水平明显低于对照组（42.62±5.96）与（75.76±13.24）。
结论
包括 rs2201841、rs11209026、rs7530511、rs11465804 和 rs1343152 在内的 IL-23R 基因多态性与银屑病无显著相关性。不同的遗传多态性可能在男女人群中银屑病的发病中起作用。不同人群之间的种族差异可能导致当前研究与其他已发表研究的多态性分布存在差异。此外，许多不同的基因、多态性和环境因素可能会影响银屑病的发展，从而影响疾病的进程。
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