Mansoura University, Mansoura, Egypt.
Arch Virol. 2012 Nov;157(11):2047-57. doi: 10.1007/s00705-012-1377-9. Epub 2012 Jun 17.
Infectious bursal disease (IBD) is a viral immunosuppressive disease of chickens attacking mainly an important lymphoid organ in birds [the bursa of Fabricius (BF)]. The emergence of new variant strains of the causative agent [infectious bursal disease virus (IBDV)] has made it more urgent to develop new vaccination strategies against IBD. One of these strategies is the use of recombinant vaccines (DNA and viral-vectored vaccines). Several studies have investigated the host immune response towards IBDV. This review will present a detailed background on the disease and its causative agent, accompanied by a summary of the most recent findings regarding the host immune response to IBDV infection and the use of recombinant vaccines against IBD.
传染性法氏囊病（IBD）是一种主要侵袭禽类重要淋巴器官[法氏囊（BF）]的病毒性免疫抑制性疾病。病原体[传染性法氏囊病病毒（IBDV）]新变异株的出现，使得开发针对 IBD 的新疫苗接种策略变得更加紧迫。这些策略之一是使用重组疫苗（DNA 和病毒载体疫苗）。有几项研究调查了宿主对 IBDV 的免疫反应。本综述将详细介绍该疾病及其病原体的背景，并总结关于宿主对 IBDV 感染的免疫反应以及使用重组疫苗预防 IBD 的最新发现。
