Zeiton M A, Knight B C, Khaled Y N, Green R, Mapstone N, Riyad K
Department of Surgery, Royal Blackburn Hospital, Blackburn, Lancashire, UK.
BMJ Case Rep. 2011 Feb 15;2011:bcr1020103426. doi: 10.1136/bcr.10.2010.3426.
Anal gland carcinoma (AGC) is rare, and its innocuous presentation and developing immunohistochemical profile make the diagnosis of it challenging. Predominant presenting symptoms include anal pain, rectal bleeding and the presence of a perianal mass in advanced stages of the disease. Histological profile commonly reveals an intramural adenocarcinoma with normal unaffected overlying anorectal mucosa. Immunohistochemical analysis shows positive staining for cytokeratin (CK) 7 and negative staining for CK20. MUC5AC expression with CK5/6 and p53 negativity has been reported. The authors report a case of a 68-year-old woman with a rapidly advancing AGC and review the current literature with respect to diagnosis and current consensus on therapeutic management.
肛门腺癌（AGC）较为罕见，其表现不明显且免疫组化特征不断变化，这使得其诊断颇具挑战性。主要的临床表现包括肛门疼痛、直肠出血以及疾病晚期出现的肛周肿物。组织学特征通常显示为壁内腺癌，其上覆盖的肛管直肠黏膜未受影响。免疫组化分析显示细胞角蛋白（CK）7染色阳性，CK20染色阴性。有报道称MUC5AC表达伴CK5/6及p53阴性。作者报告了一例68岁女性快速进展的AGC病例，并回顾了目前关于诊断及治疗管理的共识的文献。
