McDonnell-Naughton M, McGarvey C, O'Regan M, Matthews T
Department of Nursing and Health Science, Athlone Institute of Technology, Co Westmeath
Ir Med J. 2012 Apr;105(4):105-8.
A population based case control study was conducted to examine alcohol consumption and maternal smoking during pregnancy and the risk of SIDS in an Irish population. Each SIDS case (n = 287) was compared with control infants (n = 832) matched for date and place of birth for infants born from 1994 to 2001. Conditional logistic regression was used to investigate differences between Cases and Controls establishing Odds Ratio's (OR) and 95% Confidence Intervals (CI). Mothers who smoked were 3 times more likely to have a SIDS Case, and a dose response effect was apparent, with mothers smoking 1-10 cigarettes/day OR 2.93 (CI 1.50-5.71), and those smoking > 10 cigarettes/day OR 4.36 (CI 2.50-7.61). More Case mothers consumed alcohol during pregnancy than Control mothers and, within drinkers, the amount of alcohol consumed was also greater (p < 0.05). A dose response with frequency of drinking was apparent. The adjusted odds ratio for those consuming alcohol in all three trimesters was 3.59 (CI:1.40-9.20). Both of these risk factors are modifiable and need to be incorporated into antenatal education from a SIDS point of view.
开展了一项基于人群的病例对照研究，以调查爱尔兰人群孕期饮酒和孕妇吸烟情况以及婴儿猝死综合征（SIDS）的风险。将每例SIDS病例（n = 287）与1994年至2001年出生的、按出生日期和地点匹配的对照婴儿（n = 832）进行比较。采用条件逻辑回归分析病例组和对照组之间的差异，计算比值比（OR）和95%置信区间（CI）。吸烟的母亲生出SIDS患儿的可能性高出3倍，且存在剂量反应效应，每天吸1 - 10支烟的母亲OR为2.93（CI 1.50 - 5.71），每天吸烟超过10支的母亲OR为4.36（CI 2.50 - 7.61）。与对照母亲相比，更多的病例母亲在孕期饮酒，而且在饮酒的母亲中，饮酒量也更大（p < 0.05）。饮酒频率存在剂量反应效应。孕期三个阶段都饮酒者的校正比值比为3.59（CI：1.40 - 9.20）。这两个风险因素都是可以改变的，从预防婴儿猝死综合征的角度来看，需要将其纳入产前教育。
