Lin C C, Chiu H F, Yen M H, Wu C C, Chen M F
School of Pharmacy, Kaohsiung Medical College, Taiwan, Republic of China.
Am J Chin Med. 1990;18(3-4):105-12. doi: 10.1142/S0192415X90000149.
The protective effects of water extract from roots of Bupleurum kaoi Liu, Chao et Chuang and Bupleurum flacatum L. var. Komarowi Koso-Polj on CCl4-induced hepatoxicity have been investigated. Both B. kaoi (p less than 0.05) and B. falcatum var. komarowi (p less than 0.01) possessed more marked anti-hepatotoxic pharmacological effects than Bupleurum chinense DC., the typical strain widely used in Taiwan. The pathological improvement from treatment by means of the three drugs to alleviate CCl4-induced hepatic toxicity was estimated using morphological changes of hepatocytes, reduction of inflammatory cells infiltration and liver function tests.
研究了高柴胡（Bupleurum kaoi Liu, Chao et Chuang）和窄叶柴胡（Bupleurum flacatum L. var. Komarowi Koso-Polj）根水提取物对四氯化碳诱导的肝毒性的保护作用。高柴胡（p < 0.05）和窄叶柴胡（p < 0.01）均比台湾广泛使用的典型品种北柴胡（Bupleurum chinense DC.）具有更显著的抗肝毒性药理作用。通过肝细胞的形态变化、炎症细胞浸润的减少和肝功能测试，评估了这三种药物治疗以减轻四氯化碳诱导的肝毒性的病理改善情况。
