Chiu H F, Lin C C, Yang C C, Yang F
Department of Pharmacology, School of Medicine, Kaohsiung Medical College, Taiwan.
Am J Chin Med. 1988;16(3-4):127-37. doi: 10.1142/S0192415X88000194.
This study is to investigate the hepatic protective effect of several Taiwan crude drug extractions on the carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. The pharmacological and pathological effects of Bupleurum chinense, Phellodendron wilsonii, Clematis chinensis and Hedyotis corymbosa were analyzed by liver enzyme function test and pathological studies. However, the results of amine transferase SGOT and SGPT have shown a significant hepatic protective effect after treatment with Bupleurum chinense (P less than 0.005), Phellodendron wilsonii (P less than 0.001), Clematis chinensis (P less than 0.005) and Hedyotis corymbosa (P less than 0.005, SGPT only). The fatty degeneration around the central vein area and necrosis of the central lobule can be significantly improved by P. wilsonii and moderately changed by B. chinense or C. chinensis. Although fatty metamorphosis has been affected by H. corymbosa, various inflammatory cell infiltrations in the cytoplasm were noted.
本研究旨在探讨几种台湾天然药物提取物对四氯化碳（CCl4）诱导的大鼠肝毒性的肝脏保护作用。通过肝酶功能测试和病理研究分析了柴胡、黄柏、威灵仙和伞房花耳草的药理和病理作用。然而，谷丙转氨酶（SGOT）和谷草转氨酶（SGPT）的结果显示，柴胡（P<0.005）、黄柏（P<0.001）、威灵仙（P<0.005）和伞房花耳草（仅SGPT，P<0.005）治疗后具有显著的肝脏保护作用。黄柏可显著改善中央静脉周围区域的脂肪变性和中央小叶坏死，柴胡或威灵仙可使其适度改变。虽然伞房花耳草影响了脂肪变性，但在细胞质中观察到各种炎性细胞浸润。
