Guerrero-Sanchez Carlos, Keddie Daniel J, Saubern Simon, Chiefari John
Commonwealth Scientific Industrial Research Organization (CSIRO) Materials Science and Engineering , Bag 10, Clayton South VIC 3169, Australia.
ACS Comb Sci. 2012 Jul 9;14(7):389-94. doi: 10.1021/co300044w. Epub 2012 Jun 27.
An automated and parallel freeze-evacuate-thaw degassing method in a commercially available synthesizer is disclosed and tested for its applicability to reversible addition-fragmentation chain transfer (RAFT) polymerization. The effectiveness of this method to eliminate oxygen in polymerization reactions is demonstrated by directly comparing it against experiments performed using conventional laboratory techniques. Apart from the demonstrated accuracy, the proposed method has also shown significant precision when performing RAFT polymerizations. The reported experimental technique can be easily adapted to other chemical systems where the removal of oxygen is mandatory. This new high-throughput method has the potential to significantly increase the productivity and/or research outcomes in laboratories where oxygen-sensitive reactions are carried out.
公开了一种在市售合成器中自动且并行的冷冻-抽空-解冻脱气方法，并测试了其对可逆加成-断裂链转移（RAFT）聚合的适用性。通过将该方法与使用传统实验室技术进行的实验直接比较，证明了该方法在聚合反应中消除氧气的有效性。除了已证明的准确性外，所提出的方法在进行RAFT聚合时也显示出显著的精度。所报道的实验技术可以很容易地应用于其他必须去除氧气的化学体系。这种新的高通量方法有可能显著提高进行氧敏感反应的实验室的生产率和/或研究成果。
