Dept. of Hard Tissue Engineering (Pharmacology), Graduate School, Tokyo Medical & Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan.
Adv Drug Deliv Rev. 2012 Sep;64(12):1220-38. doi: 10.1016/j.addr.2012.05.017. Epub 2012 Jun 16.
Peptides are attractive as novel therapeutic reagents, since they are flexible in adopting and mimicking the local structural features of proteins. Versatile capabilities to perform organic synthetic manipulations are another unique feature of peptides compared to protein-based medicines, such as antibodies. On the other hand, a disadvantage of using a peptide for a therapeutic purpose is its low stability and/or high level of aggregation. During the past two decades, numerous peptides were developed for the treatment of bone diseases, and some peptides have already been used for local applications to repair bone defects in the clinic. However, very few peptides have the ability to form bone themselves. We herein summarize the effects of the therapeutic peptides on bone loss and/or local bone defects, including the results from basic studies. We also herein describe some possible methods for overcoming the obstacles associated with using therapeutic peptide candidates.
肽作为新型治疗试剂具有吸引力，因为它们在采用和模拟蛋白质的局部结构特征方面具有灵活性。与基于蛋白质的药物（如抗体）相比，肽具有进行有机合成操作的多种能力，这是其另一个独特特征。另一方面，将肽用于治疗目的的一个缺点是其稳定性低和/或聚集水平高。在过去的二十年中，已经开发了许多用于治疗骨疾病的肽，并且一些肽已经用于局部应用以在临床上修复骨缺损。然而，很少有肽具有自身形成骨骼的能力。本文总结了治疗肽对骨丢失和/或局部骨缺损的作用，包括基础研究的结果。本文还描述了克服使用治疗性肽候选物相关障碍的一些可能方法。
