Diamantini G, Spadoni G, Salvatori A, Duranti E, Pescador R
Istituto di Chimica Farmaceutica, Università di Urbino, Italy.
Farmaco. 1990 Jun;45(6):665-72.
The new amides are inhibitors of cholesterol biosynthesis in vitro as well as in vivo. These compounds are also inhibitors in vivo of triglyceride biosynthesis and of platelet aggregation. All tests showed activity (values expressed as percentage variation) much greater than clofibrate. Besides, all compounds have no effect on coagulation or diuresis and showed low acute toxicity.
这些新型酰胺类化合物在体外和体内均为胆固醇生物合成的抑制剂。这些化合物在体内也是甘油三酯生物合成和血小板聚集的抑制剂。所有测试均显示其活性（以百分比变化表示）远高于氯贝丁酯。此外，所有化合物对凝血或利尿均无影响，且急性毒性较低。
