SIV 感染诱导肠道黏膜中浆细胞样树突状细胞的积累。
SIV infection induces accumulation of plasmacytoid dendritic cells in the gut mucosa.
机构信息
Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, MA, USA.
出版信息
J Infect Dis. 2012 Nov;206(9):1462-8. doi: 10.1093/infdis/jis408. Epub 2012 Jun 18.
Abstract
Multiple studies suggest that plasmacytoid dendritic cells (pDCs) are depleted and dysfunctional during human immunodeficiency virus/simian immunodeficiency virus (HIV/SIV) infection, but little is known about pDCs in the gut-the primary site of virus replication. Here, we show that during SIV infection, pDCs were reduced 3--fold in the circulation and significantly upregulated the gut-homing marker α4β7, but were increased 4-fold in rectal biopsies of infected compared to naive macaques. These data revise the understanding of pDC immunobiology during SIV infection, indicating that pDCs are not necessarily depleted, but instead may traffic to and accumulate in the gut mucosa.
摘要
多项研究表明，在人类免疫缺陷病毒/猴免疫缺陷病毒（HIV/SIV）感染期间，浆细胞样树突状细胞（pDCs）会被耗尽并且功能失调，但人们对肠道中 pDCs（病毒复制的主要部位）的了解甚少。在这里，我们发现，在 SIV 感染期间，循环中的 pDCs 减少了 3 倍，并且显著上调了肠道归巢标记物 α4β7，但与未感染的猕猴相比，感染猕猴的直肠活检中 pDCs 增加了 4 倍。这些数据修正了人们对 SIV 感染期间 pDC 免疫生物学的理解，表明 pDCs 不一定被耗尽，而是可能迁移并在肠道黏膜中积累。
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