浆细胞样树突状细胞在自身免疫和慢性病毒感染中的致病作用。
A pathogenic role of plasmacytoid dendritic cells in autoimmunity and chronic viral infection.
机构信息
Autoimmunity and Inflammation Program, HSS Research Institute, Hospital for Special Surgery, New York, NY
Department of Microbiology and Immunology, Weill Cornell Medical College of Cornell University, New York, NY.
出版信息
J Exp Med. 2019 Sep 2;216(9):1974-1985. doi: 10.1084/jem.20181359. Epub 2019 Aug 16.
Abstract
Following the discovery of plasmacytoid dendritic cells (pDCs) and of their extraordinary ability to produce type I IFNs (IFN-I) in response to TLR7 and TLR9 stimulation, it is assumed that their main function is to participate in the antiviral response. There is increasing evidence suggesting that pDCs and/or IFN-I can also have a detrimental role in a number of inflammatory and autoimmune diseases, in the context of chronic viral infections and in cancers. Whether these cells should be targeted in patients and how much of their biology is connected to IFN-I production remains unclear and is discussed here.
摘要
在发现浆细胞样树突状细胞 (pDC) 及其对 TLR7 和 TLR9 刺激产生 I 型干扰素 (IFN-I) 的非凡能力后，人们认为其主要功能是参与抗病毒反应。越来越多的证据表明，pDC 和/或 IFN-I 在慢性病毒感染和癌症的情况下，也可能在多种炎症性和自身免疫性疾病中发挥有害作用。这些细胞是否应该在患者中进行靶向治疗，以及它们的生物学与 IFN-I 产生有多少关联，目前仍不清楚，本文对此进行了讨论。
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