Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Acta Neurol Scand. 2013 Mar;127(3):186-91. doi: 10.1111/j.1600-0404.2012.01696.x. Epub 2012 Jun 19.
The aim of this study was to examine the association between hangover and the risk of stroke.
A population-based sample of men with an average follow-up of 15.7 years. 2466 men with no history of stroke at baseline participated. Two hundred and six strokes occurred, of which 167 were ischemic strokes.
The age-adjusted, relative risk (RR) for any stroke among men with ≥1 hangover per year was 2.33-fold (95% confidence interval (CI), 1.19-4.56; P = 0.013) relative to men without hangover, and 2.99-fold (95% CI, 1.52-5.86; P = 0.001) for ischemic stroke, respectively. After adjustment for age, smoking, high density lipoprotein (HDL)-cholesterol, LDL-cholesterol, BMI, SBP, myocardial ischemia during exercise, symptomatic coronary heart disease (CHD) and CHD in family, C-reactive protein, diabetes, and total alcohol consumption, the RR for any stroke was 1.94-fold (95% CI, 0.95-3.96; P = 0.070) and 2.58-fold (95% CI, 1.24-5.36; P = 0.011) for ischemic stroke among men with hangovers. Additional adjustment of atrial fibrillation and cardiac failure and risk was 2.45-fold (95% CI, 1.18-5.12; P = 0.017) for ischemic strokes.
This study shows that at least one hangover a year is related to an increased risk of ischemic stroke in men.
本研究旨在探讨宿醉与中风风险之间的关联。
本研究采用基于人群的男性样本，平均随访时间为 15.7 年。共有 2466 名基线时无中风病史的男性参与了研究。共有 206 例中风发生，其中 167 例为缺血性中风。
校正年龄后，每年至少有 1 次宿醉的男性发生任何类型中风的相对风险（RR）为 2.33 倍（95%置信区间（CI），1.19-4.56；P = 0.013），缺血性中风的 RR 为 2.99 倍（95%CI，1.52-5.86；P = 0.001）。在校正年龄、吸烟、高密度脂蛋白（HDL）-胆固醇、LDL-胆固醇、BMI、SBP、运动时心肌缺血、有症状的冠心病（CHD）和家族性 CHD、C 反应蛋白、糖尿病和总酒精摄入量后，RR 为任何类型中风为 1.94 倍（95%CI，0.95-3.96；P = 0.070）和缺血性中风为 2.58 倍（95%CI，1.24-5.36；P = 0.011）。在校正心房颤动和心力衰竭后，RR 为缺血性中风为 2.45 倍（95%CI，1.18-5.12；P = 0.017）。
本研究表明，每年至少有 1 次宿醉与男性发生缺血性中风的风险增加有关。
