Department of Gastroenterology, Sunway Medical Centre, Selangor Department of Gastroenterology, University of Malaya, Kuala Lumpur, Malaysia.
J Dig Dis. 2012 Jul;13(7):342-9. doi: 10.1111/j.1751-2980.2012.00599.x.
Helicobacter pylori (H. pylori) infection is reported to be associated with many extragastrointestinal manifestations, such as hematological diseases [idiopathic thrombocytopenic purpura (ITP) and unexplained iron deficiency anemia (IDA)], cardiovascular diseases (ischemic heart diseases), neurological disorders (stroke, Parkinson's disease, Alzheimer's disease), obesity and skin disorders. Among these, the best evidence so far is in ITP and unexplained IDA, with high-quality studies showing the improvement of IDA and ITP after H. pylori eradication. The evidence of its association with coronary artery disease is weak and many of the results may be erroneous. The role of H. pylori infection in affecting serum leptin and ghrelin levels has attracted a lot of attention recently and available data to date have been conflicting. There have also been many uncontrolled, small sample studies suggesting an association between H. pylori infection and neurological disorders or chronic urticaria. However, more studies are required to clarify such proposed causal links.
幽门螺杆菌（H. pylori）感染与许多胃肠道外表现有关，如血液系统疾病（特发性血小板减少性紫癜 [ITP] 和原因不明的缺铁性贫血 [IDA]）、心血管疾病（缺血性心脏病）、神经系统疾病（中风、帕金森病、阿尔茨海默病）、肥胖和皮肤疾病。在这些疾病中，目前为止最有证据的是 ITP 和原因不明的 IDA，高质量的研究表明根除 H. pylori 后 IDA 和 ITP 得到改善。其与冠心病的相关性证据较弱，许多结果可能是错误的。最近，幽门螺杆菌感染对血清瘦素和胃饥饿素水平的影响引起了广泛关注，目前可用的数据相互矛盾。也有许多未经控制的小样本研究表明幽门螺杆菌感染与神经系统疾病或慢性荨麻疹之间存在关联。但是，需要更多的研究来阐明这些拟议的因果关系。
