用于研究肠毒素型产气荚膜梭菌感染发病机制的动物模型。
Animal models to study the pathogenesis of enterotoxigenic Clostridium perfringens infections.
机构信息
California Animal Health and Food Safety Laboratory System, San Bernardino Branch, School of Veterinary Medicine, University of California, Davis, San Bernardino, CA 92408, USA.
出版信息
Microbes Infect. 2012 Oct;14(12):1009-16. doi: 10.1016/j.micinf.2012.06.003. Epub 2012 Jun 17.
Abstract
Rabbits, mice, rats, non-human primates, sheep and cattle have been used to study the effect of Clostridium perfringens enterotoxin (CPE). CPE produces mostly necrosis of the small intestinal epithelium along with fluid accumulation in rabbits and mice. In the latter, CPE can bind to internal organs such as the liver, which induces lethal potassium levels in blood.
摘要
兔子、老鼠、大鼠、非人灵长类动物、绵羊和牛已被用于研究产气荚膜梭菌肠毒素 (CPE) 的作用。CPE 主要在兔子和小鼠中引起小肠上皮细胞坏死和液体积聚。在后者中，CPE 可以与肝脏等内部器官结合，导致血液中致命的钾水平。
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