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本文引用的文献

1
Specificity of interaction between clostridium perfringens enterotoxin and claudin-family tight junction proteins.产气荚膜梭菌肠毒素与紧密连接蛋白家族 Claudin 之间相互作用的特异性。
Toxins (Basel). 2010 Jul;2(7):1595-611. doi: 10.3390/toxins2071595. Epub 2010 Jun 24.
2
On the interaction of Clostridium perfringens enterotoxin with claudins.关于产气荚膜梭菌肠毒素与紧密连接蛋白相互作用的研究。
Toxins (Basel). 2010 Jun;2(6):1336-56. doi: 10.3390/toxins2061336. Epub 2010 Jun 8.
3
Structure of the food-poisoning Clostridium perfringens enterotoxin reveals similarity to the aerolysin-like pore-forming toxins.食物中毒性产气荚膜梭菌肠毒素的结构揭示了与 aerolysin 样孔形成毒素的相似性。
J Mol Biol. 2011 Oct 14;413(1):138-49. doi: 10.1016/j.jmb.2011.07.066. Epub 2011 Aug 3.
4
Development and application of a mouse intestinal loop model to study the in vivo action of Clostridium perfringens enterotoxin.研究产气荚膜梭菌肠毒素体内作用的小鼠肠袢模型的建立与应用。
Infect Immun. 2011 Aug;79(8):3020-7. doi: 10.1128/IAI.01342-10. Epub 2011 May 31.
5
Crystal structure of Clostridium perfringens enterotoxin displays features of beta-pore-forming toxins.产气荚膜梭菌肠毒素的晶体结构显示了β-孔形成毒素的特征。
J Biol Chem. 2011 Jun 3;286(22):19549-55. doi: 10.1074/jbc.M111.228478. Epub 2011 Apr 12.
6
Foodborne illness acquired in the United States--major pathogens.食源性疾病在美国的感染情况——主要病原体。
Emerg Infect Dis. 2011 Jan;17(1):7-15. doi: 10.3201/eid1701.p11101.
7
Identification of a claudin-4 residue important for mediating the host cell binding and action of Clostridium perfringens enterotoxin.鉴定与产气荚膜梭菌肠毒素介导宿主细胞结合和作用相关的紧密连接蛋白 4 残基。
Infect Immun. 2010 Jan;78(1):505-17. doi: 10.1128/IAI.00778-09. Epub 2009 Nov 2.
8
Age-related changes of claudin expression in mouse liver, kidney, and pancreas.小鼠肝脏、肾脏和胰腺中紧密连接蛋白表达的年龄相关性变化。
J Gerontol A Biol Sci Med Sci. 2009 Nov;64(11):1146-53. doi: 10.1093/gerona/glp118. Epub 2009 Aug 19.
9
Noncytotoxic Clostridium perfringens enterotoxin (CPE) variants localize CPE intestinal binding and demonstrate a relationship between CPE-induced cytotoxicity and enterotoxicity.无细胞毒性的产气荚膜梭菌肠毒素（CPE）变体定位CPE肠道结合位点，并证明CPE诱导的细胞毒性和肠毒性之间的关系。
Infect Immun. 2008 Aug;76(8):3793-800. doi: 10.1128/IAI.00460-08. Epub 2008 May 27.
10
Compositional and stoichiometric analysis of Clostridium perfringens enterotoxin complexes in Caco-2 cells and claudin 4 fibroblast transfectants.产气荚膜梭菌肠毒素复合物在Caco-2细胞和紧密连接蛋白4成纤维细胞转染子中的组成和化学计量分析。
Cell Microbiol. 2007 Nov;9(11):2734-55. doi: 10.1111/j.1462-5822.2007.00994.x. Epub 2007 Jun 24.

用于研究肠毒素型产气荚膜梭菌感染发病机制的动物模型。

Animal models to study the pathogenesis of enterotoxigenic Clostridium perfringens infections.

机构信息

California Animal Health and Food Safety Laboratory System, San Bernardino Branch, School of Veterinary Medicine, University of California, Davis, San Bernardino, CA 92408, USA.

出版信息

Microbes Infect. 2012 Oct;14(12):1009-16. doi: 10.1016/j.micinf.2012.06.003. Epub 2012 Jun 17.

DOI:10.1016/j.micinf.2012.06.003
PMID:22713745
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3572749/
Abstract

Rabbits, mice, rats, non-human primates, sheep and cattle have been used to study the effect of Clostridium perfringens enterotoxin (CPE). CPE produces mostly necrosis of the small intestinal epithelium along with fluid accumulation in rabbits and mice. In the latter, CPE can bind to internal organs such as the liver, which induces lethal potassium levels in blood.

摘要

兔子、老鼠、大鼠、非人灵长类动物、绵羊和牛已被用于研究产气荚膜梭菌肠毒素 (CPE) 的作用。CPE 主要在兔子和小鼠中引起小肠上皮细胞坏死和液体积聚。在后者中，CPE 可以与肝脏等内部器官结合，导致血液中致命的钾水平。