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具有光谱反向响应和强非对称共振场分布的敏感金属层辅助导模共振生物传感器。

Sensitive metal layer assisted guided mode resonance biosensor with a spectrum inversed response and strong asymmetric resonance field distribution.

作者信息

Lin Sheng-Fu, Wang Chih-Ming, Ding Ting-Jou, Tsai Ya-Lun, Yang Tsung-Hsun, Chen Wen-Yih, Chang Jenq-Yang

机构信息

Department of Optics and Photonics, National Central University, Jhongli 32001, Taiwan.

出版信息

Opt Express. 2012 Jun 18;20(13):14584-95. doi: 10.1364/OE.20.014584.

DOI:10.1364/OE.20.014584
PMID:22714520
Abstract

In this paper, a metal layer assisted guide mode resonance (MaGMR) device with high sensitivity is proposed for bioanalytical applications and its functioning is experimentally proved. We find that the reflection spectra present a unique inversed response. The resonance mechanism is also discussed. Numerical calculation results indicate that the high sensitivity performance of MaGMR comes from the strongly asymmetric resonance modal profile and low propagation angle inside the waveguide. There is a one-fold enhancement of the evanescent wave in the analytes region compared to typical GMR. According to the experimental results, the proposed MaGMR achieved a bulk sensitivity of 376.78 nm/RIU in fundamental TM mode resonating at 0.809 μm with the first diffraction angle. Experiment results show a 264.78% enhancement in the sensitivity compared to that of the typical GMR sensor in the same resonance conditions of TM mode.

摘要

本文提出了一种用于生物分析应用的具有高灵敏度的金属层辅助导模共振(MaGMR)器件,并通过实验证明了其功能。我们发现反射光谱呈现出独特的反向响应。还讨论了共振机制。数值计算结果表明,MaGMR的高灵敏度性能源于波导内强烈不对称的共振模态分布和低传播角。与典型的GMR相比,分析物区域的倏逝波增强了一倍。根据实验结果,所提出的MaGMR在0.809μm的基模TM模式下以第一衍射角实现了376.78nm/RIU的体灵敏度。实验结果表明,在TM模式的相同共振条件下,与典型的GMR传感器相比,灵敏度提高了264.78%。

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