Nightingale Helen, Witherick Jonathan, Wilkins Alastair
University of Bristol, Bristol, UK.
BMJ Case Rep. 2011 Feb 2;2011:bcr1020103444. doi: 10.1136/bcr.10.2010.3444.
Longitudinally extensive transverse myelitis (LETM) is a neurological condition characterised by a contiguous inflammatory lesion of the spinal cord. LETM is often associated with the autoimmune central nervous system disease neuromyelitis optica (NMO) and rarely with multiple sclerosis. The discovery of the NMO-IgG antibody, provides a useful serological marker of LETM associated with the NMO disease spectrum (LETM and/or optic neuritis). Here, the authors report two cases of LETM, which differ in disease severity and NMO-IgG antibody serological status.
长节段横贯性脊髓炎（LETM）是一种以脊髓连续性炎性病变为特征的神经系统疾病。LETM常与自身免疫性中枢神经系统疾病视神经脊髓炎（NMO）相关，很少与多发性硬化症相关。NMO-IgG抗体的发现为与NMO疾病谱（LETM和/或视神经炎）相关的LETM提供了一种有用的血清学标志物。在此，作者报告了两例LETM病例，这两例病例在疾病严重程度和NMO-IgG抗体血清学状态方面存在差异。
