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一名72岁男性上肢无力伴横贯性脊髓炎

Transverse Myelitis in a 72-Year-Old Male Presenting With Upper Extremity Weakness.

作者信息

Cox Hannah, Virgilio Richard, Yuhico Luke

机构信息

Internal Medicine, Edward Via College of Osteopathic Medicine, Auburn, USA.

Clinical Affairs, Edward Via College of Osteopathic Medicine, Auburn, USA.

出版信息

Cureus. 2024 Jul 30;16(7):e65762. doi: 10.7759/cureus.65762. eCollection 2024 Jul.

Abstract

Acute transverse myelitis (TM) is a rare, acquired neuro-immune spinal cord disorder that can be idiopathic or related to a secondary disease. Clinical signs and symptoms include motor weakness, sensory alterations, and bowel or bladder dysfunction. Often TM occurs in the younger population or middle-aged adults. This patient's presentation is unique in the fact that he does not fall into either of these age categories. In this case, a 72-year-old male with a past medical history of hypertension and type 2 diabetes mellitus presented to the emergency department due to a five-day history of worsening weakness of the upper extremities bilaterally. In addition, the patient reported a new onset of abdominal wall numbness. The patient reported being at a theme park a few days prior, denying any injuries and only complaining of neck discomfort during the car ride home. Labs and imaging were quickly ordered for diagnostic purposes. The patient was diagnosed with TM using magnetic resonance imaging (MRI), lumbar puncture, and clinical signs. The etiology was later discovered to be due to a new diagnosis of Sjögren's autoimmune disease. The patient was treated with high-dose intravenous steroids for five days while being monitored for any neurologic changes. The plan was to continue steroids by mouth once discharged from the hospital. Due to poor adherence to discharge instructions, the patient was readmitted after presenting to the emergency department with worsening symptoms. Physicians need to recognize and diagnose TM quickly, as some etiologies are treatable and can prevent further damage to the spinal cord.

摘要

急性横贯性脊髓炎(TM)是一种罕见的、后天获得性神经免疫性脊髓疾病,可为特发性或与继发性疾病相关。临床体征和症状包括运动无力、感觉改变以及肠道或膀胱功能障碍。TM常发生于年轻人或中年成年人。该患者的表现较为独特,因为他不属于这两个年龄类别中的任何一种。在本病例中,一名72岁男性,有高血压和2型糖尿病病史,因双侧上肢无力加重5天而就诊于急诊科。此外,患者报告出现了新的腹壁麻木。患者称几天前在一个主题公园游玩,否认有任何受伤情况,仅在乘车回家途中抱怨颈部不适。为明确诊断,迅速安排了实验室检查和影像学检查。通过磁共振成像(MRI)、腰椎穿刺及临床体征,该患者被诊断为TM。后来发现病因是新诊断的干燥综合征自身免疫疾病。患者接受了为期5天的大剂量静脉注射类固醇治疗,期间监测有无任何神经学变化。计划是出院后继续口服类固醇。由于患者对出院指导依从性差,在因症状加重再次就诊于急诊科后被再次收治。医生需要快速识别和诊断TM,因为一些病因是可治疗的,且能防止脊髓进一步受损。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a60/11361401/752c83c3b1fa/cureus-0016-00000065762-i01.jpg

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