Lakhanpal Arun, Arfon Sian, McKeon Damian John
Department of Respiratory Medicine, Ysbyty Gwynedd Hospital, Bangor, Gwynedd, UK.
BMJ Case Rep. 2011 Feb 2;2011:bcr1120103493. doi: 10.1136/bcr.11.2010.3493.
Non-tubercular mycobacteriae (NTM) are ubiquitous organisms found throughout the environment including soil and water. Incidence of NTM infection or isolation is increasing both in immunocompromised as well as immunocompetent patients and may present with a spectrum of disease similar to tuberculosis. The authors report cases of two patients with a background of cancer who presented with NTM infection mimicking lung cancer. The case report is followed by review of reported cases of NTM infections which presented similarly mimicking cancer. Based on their experience and the review of literature the authors recommend that all efforts should be made to obtain tissue for histology and acid fast bacilli examination in all cases which present with lung masses, nodules, bronchiectasis, air-space shadowing or cavity formation especially over a background of structural lung disease. Such cases should be kept under close clinical and radiological follow-up, as cancer and NTM infections can coexist.
非结核分枝杆菌(NTM)是广泛存在于包括土壤和水在内的整个环境中的微生物。NTM感染或分离的发生率在免疫功能低下和免疫功能正常的患者中均呈上升趋势,并且可能表现出一系列与结核病相似的疾病。作者报告了两例有癌症背景的患者,他们表现出类似肺癌的NTM感染。病例报告之后是对报告的类似癌症表现的NTM感染病例的综述。基于他们的经验和文献综述,作者建议,对于所有出现肺部肿块、结节、支气管扩张、气腔阴影或空洞形成的病例,尤其是在结构性肺病背景下,应尽一切努力获取组织进行组织学和抗酸杆菌检查。此类病例应进行密切的临床和放射学随访,因为癌症和NTM感染可能同时存在。